摘要
37例发病24小时内的首次急性心肌梗塞患者,随机分为溶栓组和对照组,溶栓组用尿激酶、肝素及阿斯匹林治疗,并采用创伤性和非创伤性冠脉再通指标观察两组治疗效果。结果提示:溶栓组冠脉再通率优于对照组(P<0.05),近期死亡率较对照组低(分别为5.3%与21.1%);溶栓组内,发病时间<6b与6～24h两组疗效无显著差异。故认为急性心肌梗塞溶栓治疗的时机可延长至发病后24h。
Thirty seven patients with first attack of acute myocardial infarction within 24hours after onset of symptoms were randomized to thrombolytic therapygroup (n=19) and control group (n=18). Thrombolytic therapy group usedurokinase, heparin and aspirin. We used invasive and non-invasivecoronary patency standards to observe the response of either therapy. The study suggests that coronary patency rate was higher in urokinase thrombolytic therapy group than in control group (P<0.05); the short-termmortality was also lower(5.3%vs 21.1%). However, there was no significant difference in patency rate intra-thrombolytic-therapy group between those within 6 hours and those within 6-24 hours after onset of symptoms. Hence the time of thrombolytic therapy in AMI could remain effective in case there had been a delay but still within 24h after the onset of symptoms.
出处
《上海第二医科大学学报》
CSCD
1992年第4期290-293,共4页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
心肌梗塞
尿激酶
溶栓疗法
acute myocardial infarction urokinase thrombolytic therapy left ventricular function
