摘要
目的 为观察前列腺素E1 (PGE1 )对糖尿病周围神经病变的作用设计此实验。方法 治疗组 10 5例糖尿病周围神经病变患者给予PGE1 针剂 90 μg溶于生理盐水 5 0 0ml中静脉滴注 ,每天一次。两周一疗程 ,每疗程间歇4～ 5天 ,共两个疗程。结果 PGE1 能有效改善或减轻糖尿病周围神经病变所致的疼痛、麻木和其它感觉障碍。总有效率为 93.33% ,同对照组相比有显著差异性 (P <0 .0 0 1)。尽管治疗前后周围神经的传导速度有所增加 ,但经统计学比较两者无显著差异性。结论 PGE1 能有效地改善或减轻糖尿病周围神经有病变所引起的疼痛、麻木、缩小感觉障碍、麻木、缩小感觉障碍平面。
Objective In order to study the effect of PGE 1 on diabetic neuropathy. Methods: 65 Cases of diabetes mellites with peripheral neuropathy were given daily intravenonse injection of PGE 1 (90 ug)for four weeks. The Control group(50cases) were given VitaminBl table 30mg/d and Asprin 50mg/d. Results: After four weeks, the treatment group an effective rate 93.33% increased significantly that of the control group(P<0.001). but unchanged Nerve Conduction Velocity(NCV) in treatment. Conclusion: PGE 1 is one of the choices in diabetic neuropathy. There data suggested indirectly that endoneurial capillary abnormality played an important role in diabetic neuropathy an.
出处
《海南医学》
CAS
2001年第8期27-28,共2页
Hainan Medical Journal
