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A型流感病毒血凝素、神经氨酸酶DNA疫苗研究 被引量：5

Protection and Response Against Influenza A Virus Infection by Hemagglutinin, Neuraminidase DNA Vaccine
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摘要 用BALB/C小鼠为模型,检测A型流感病毒血凝素、神经氨酸酶、基质蛋白DNA疫苗抗流感能力。研究表明:血凝素、神经氨酸酶DNA疫苗能提供有效的抗流感保护;血凝素、神经氨酸酶和基质蛋白联合免疫动物提供最佳免疫保护。 Use BALB/C mice as animal model to examine the ability of influenza hemagglutinin, neuraminidase, marix DNA vaccine to protect against homologous or heterologous virus infection. The results show hemaggludnin, neuraminidase DNA vaccine could provide protection against lethal influenza virus. In addition, mixture of HA, NA, Ml provide more protection, particularly against different strain of virus.
作者 陈则
机构地区 晓庄学院生命科学院
出处 《微生物学杂志》 CAS CSCD 2003年第5期1-4,11,共5页 Journal of Microbiology
基金 国家863计划(2001AA213051) 国家自然科学基金(C01010801) 中科院百人计划及院领域前沿研究资助
关键词 DNA疫苗 流感病毒 血凝素 神经氨酸酶 DNA vaccine, influenza, hemagglutinin, neuraminidase.
分类号 R373.13 [医药卫生—病原生物学]
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参考文献22

  • 1Ulmer JB, Donnelly JJ, Paker SE, Rhodes GH, Felgner PL,Dwarki VJ et al. Heterologous protection against influenza by injection of DNA encoding a viral protein[J]. Science 1993,259:1745- 9.
  • 2Fynan EF, Webster RG, Fuller DH, Hayncs JR, Santoro JC,Robinson HL. DNA vaccines: protective immunizations by parenteral ,mucosal ,and gene gun inoculations [J].Proc Natl Acad Sci .USA 1993,90:11478--82.
  • 3Robinson HL, Hunt LA, Webster RG. Protection against a lethal influenza virus challenge by immunization with a hemagglutinin-expressing plasmid DNA [J].Vaccine 1993,11 : 957-60.
  • 4Webster RG, Fynan EF, Santoro JC, Robinson H. Protection of ferrets against influenza challenge with a DNA vaccine to the hemagglutinin[J].Vaccine 1994,12:1495--8.
  • 5Raz E, Carson DA, Parker SE et al. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses[J]. Proc Natl Acad Sci. USA 1994,91:9519--23.
  • 6Ulmer JB, Deck RR, DeWitt CM, Friedman A, Donnelly JJ,Liu MA. Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines[J]. Vaccine 1994,12:1541--4.
  • 7Donnelly JJ , Friedman A , Martinez D , Montgomery DL ,Shiver JW, Motzel SL, Ulmer JB, Liu MA. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus [ J ]. Nat Med. 1995, 1 :583--7.
  • 8Chert Z, Sahashi Y, Matuo K, Asanuma H, Takahashi H, Iwasaki T, Suzuki Y, Aizawa C, Kurata T, Tamura S I. Comparison of the ability of viral protein-expressing plasmid DNAs toprotect against influeaza[J]. Vaccine 1998. In press.
  • 9Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector [J]. Gene 1991,108:193--200.
  • 10Yetter RA, Lehrer S, Ramphal R, Small PA, Jr. Outcome of influenza infection, effect of site of initial infection and heterotypic immunity [J]. Infect Immun. 1980,29:654-62.

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微生物学杂志
2003年 第5期

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