摘要
目的:了解利巴韦林(ribavirin,RBV)对严重急性呼吸综合征(SARS)患者血红蛋白的影响。方法:以57例使用了利巴韦林的SARS患者为观察对象,对治疗前后血红蛋白的变化与利巴韦林总用药时间、累积总量、日用药量的关系进行分析。结果:用药前、后血红蛋白水平相比差异显著(P<0.05)。血红蛋白下降的幅度与利巴韦林累积总量及总用药时间无关;而与该药的每日用量相关(P<0.01)。结论:利巴韦林每日用量对SARS患者血红蛋白影响大,推荐临床小剂量使用利巴韦林。
Objective:To observe the effect of ribavirin on hemoglobin(Hb )of SARS patients.Method:Hb changes were detected in57SARS patients around the period of ribavirin administration.Results:Estimation of Hb levels showed signifi-cant difference between before and after the start of treating(P<0.05).Hb drop was associated with daily dosage of ribavirin(P<0.05),not with its cumulative action and teatment duration.Con clusion:Ribavirin of lower dose daily is recommended in clinical practice of anti-SARS so as to avoid its adverse effects on Hb.
出处
《药物不良反应杂志》
2003年第5期297-301,共5页
Adverse Drug Reactions Journal
