摘要
目的 观察 NP方案化疗联合伊班膦酸钠治疗肺癌骨转移的疗效。方法 把 5 8例骨转移的肺癌患者分为治疗组 (2 8例 )和对照组 (30例 )。治疗组在化疗间歇期使用伊班膦酸钠注射液 ,对照组为单纯化疗。化疗 2疗程后观察生活质量、骨痛评分、血清 AL P及 Ca+ + 水平的变化 ,肿瘤疗效及副作用。结果 两组生活质量、骨痛评分、血清 AL P及 Ca+ + 水平的变化差异有显著性 (p<0 .0 5 ) .肿瘤疗效差异不显著 (p>0 .0 5 ) ,且无明显副作用。结论 伊班膦酸钠注射液治疗和预防肺癌骨转移安全、有效及副作用不明显。
Objective To investigate the response rate of chemotherapy combined Ibandronate Injection(AIBEN) on patients with lung cancer bone metastasis.Methods 58 patients with lung cancer bone metastasis were divided into two groups: AIBEN(treated with AIBEN, n=28) and controls(with regular chemotherapy treatment, n=30). After chemotherapy, the measures of life quality, therapeutic response, ALP, Ca2+ in their blood examination, tumor effectiveness and toxic effect were studied. Results The group differences of life quality, therapeutic response, ALP, Ca2+ in their blood examination were significant different(P<0.05). There was no difference on tumor effectiveness(P>0.05). No toxic effect was observed.Conclusion Ibandronate Injection is a safe, well tolerated and effective treatment for bone metastasis. It can be widely used.
出处
《临床肺科杂志》
2003年第6期495-496,共2页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
骨转移
化疗
伊班膦酸钠
Ibandronate Bone Metastasis Lung Cancer Life Quality
