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干细胞与糖尿病治疗 被引量：1

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摘要 干细胞诱导分化为胰岛 β细胞以重建胰岛为糖尿病的治疗开辟了新途径。胚胎干细胞和成体干细胞是较好的用于细胞替代治疗的细胞来源 ,但干细胞参与糖尿病治疗还存在取材困难 ,分离困难等问题。葡萄糖及成纤维细胞生长因子是胰岛 β细胞基因表达的重要影响因子。
作者 屈纪富 郝利 孟萍 艾智华 程天民
机构地区 重庆市第三军医大学全军复合伤研究所 重庆市第三军医大学附属西南医院内分泌科
出处 《国外医学（生理病理科学与临床分册）》 2003年第5期471-473,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 国家自然科学基金 (30 2 0 0 12 9) 973项目 (G19990 5 42 0 5 )
关键词 胰岛Β细胞 干细胞 分化
分类号 R587.1 [医药卫生—内分泌]
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参考文献20

  • 1Wakayama T, Tabar V, Rodriguez I, et al. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer[J]. Science, 2001, 292(5517): 740-743.
  • 2Oshima H, Rochat A. Kedzia C. Morphogenesis and renewal of hair fillicles from adult nmhipotent stem cells [ J]. Cell, 2001. 104( 2 ) : 233-245.
  • 3Wei G, Schubiger G, Harder F, et al. Stem cell plasticity in mammals and transdetermination in Drosophila: common themes [ J ]. Stem Cells. 2000, 18(6) : 409-414.
  • 4Soria B. Roche E, Berna G. et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice [J]. Diabetes. 2000, 49 ( 2 ) : 157-162.
  • 5Assady S, Maor , Amit M, et al. Insulin production by human embryonic stem cells[J]. Diabetes, 2001 , 50(8) :1691-1697.
  • 6Schwitzgebel VM, Scheel DW, Conners JR, et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas[J]. Development. 2000. 127(16) :3533-3542.
  • 7Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets[J]. Science. 2001.292(5520) : 1389-1394.
  • 8Mezey E. Chandross K J, ttarta G. et al. Turning blood into brain : cells bearing neuronal antigens generated in vivo from bone marrow [J]. Science, 2000. 290( 5497 ) : 1779-1782.
  • 9Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus[ J]. Am J Physiol Endocrinol Metab ,2003,284( 2 ) : E259-E266.
  • 10Bouwens L. Transdifferentiation versus stem cell hypothesis for the regeneration of isletbeta-cells in the pancreas [ J ]. Microsc Res Teeh, 1998, 43(4) :332-336.

同被引文献17

  • 1洪天配,杨金奎.2006年国际糖尿病联盟第19届世界糖尿病大会专题报道.
  • 2Wolffenbuttel BH,Vreeburg J.Insulin.Therapy does not diminish beta-cell damage in the ncormtal streptozotocin-injected rat[J].Diabetcs Res,1988,9(2):77-79
  • 3Montana E,Bonner-Weir S,Weir GC.Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice[J].J Clin Invest 91:780-787 Endocrinology
  • 4Assady S,Maor G,Amit M,et al.Insulin production by human embryonic stem cells[J].Diabetes,2001,50(8):1691-1697
  • 5Soda B,Roche E,Bema G,et al.Insulin-secreting cells derived from embryonic stern cells normalize glycemia in streptozotocin induced diabetic mice[J].Diabetes,2000,49(2):157-162.
  • 6Lumelsky N,Blondel O,Laeng P,et al.Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets[J].Science,2001,292(5520):1389-1394
  • 7Peck AB,Chaudhari M,Cornelius 3G,et al.Pancreatic stem cells:building blocks for a better surrogate islet to treat type 1 diabetes[J].Ann Med.2001,33(3):186-192
  • 8Ramiya VK,Maraist M,Arfors KE,et al.Reversal of insulindependent diabetes usingislet generated in vitro from pancreatic stem cells[J].Nat Med,2000,6(6):278-282
  • 9Bonnet-Weir S,Taneja M,Weir GC,Tatarkiewicz K,Song.In vitro cultivation of human islets from expanded ductal tissue[J].Proc Natl Acad Sci USA.2000;97(4):7999-8004
  • 10Oh SH,Muzzonigro TM,Bae SH,La Plante JM,Hatch HM,Petersen BE.Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type Ⅰ diabetes[J].Lab Invest,2004,84(5):607-617

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国外医学（生理病理科学与临床分册）
2003年 第5期

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