3Halushka MK, Fan JB, Bentley K, Hsie L, et al. Patterns of single - nucleotide polymorphisms in candidate geaes for blood- pressure homeostasis[J]. Nat Genet, 1999, 22(3) :239-247.
4Cargill M, Altshuler D, Ireland J, Sklar P, et al. Characterization of single- nucleotide polymorphisms in coding regions of human genes[J]. Nat Genet, 1999, 22(3) :231-238.
5Chasman D, Adams RM. Predicting the functional consequences of non- synonymous single nucleotide polymorphisms: structure -based assessment of amino acid variation[J]. J Mol Biol, 2001,307(2) : 683-706.
6Sunyaev S, Ramensky V, Koch I, Lathe W 3rd, Kondrashov AS, Bork P. Prediction of deleterious human alleles[J]. Hum Mol Genet, 2001, 10(6) :591-597.
8Rafalski F. Application of single nucleotide polymorphisms in crop genetics[J]. Current Opinion in Plant Biology, 2002, 5:94-100.
9Picoult -Newberg L, Ideker TE, Pohl MG, Taylor, et al.Mining SNPs from EST databases[J]. Genome Res,1999,9(2):167-174.
10Brookes AJ, Lehv? slaiho H, Siegfried M, Boehm JG, et al. HGBASE: a database of SNPs and other variations in and around human genes[J]. Nucleic Acids Research, 2000, 28(1):356-360.
二级参考文献13
1Wang D G，Science，1997年，280卷，1077页
2King H,Aubert R E,Herman W H,et al.Global burden of diab etes,1995-2025:prevalence,numerical estimates,and projections [J].Diabetes Ca re,1998,21:1414-1431.
3Martin E R,Lai E H,Gilbert J R,et al.SNPing away at complex di seases:analysis of single-nucleotide polymorphisms around APOE in Alzheimer dis ease [J].Am J Hum Genet,2000,67:383-394.
4Horikawa Y,Oda N,Cox N J,et al.Genetic variation in gene encod ing calpain-10 is associated with type 2 diabetes mellitus [J].Nature genet,2 000,26:163-175.
5Johnson G C,Todd J A.Strategies in complex disease mapping [J ].Curr Opin Genet Devel,2000,10:330-334.
6Mullikin J C,Hunt S E,Cole C G,et al.An SNP map of human chrom osome 22 [J].Nature,2000,407:516-520.
7Brookes A J.The essence of SNPs [J].Gene,1999,234:177-186.
8Kruglyak L.The use of a genetic map of biallelic markers in li nkage studies [J].Nature Genet,1997,17:21-24.
9Alderborn A,Kristofferson A,Hammerling U,et al.Determination o f single-nucleotide polymorphisms by real-time pyrophosphate DNA sequencing [ P].Genome Res,2000,10:1249-1258.
10Chen J,Iannone M A,Li M S,et al.A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain ext ension [P].Genome Res,2000,10:549-557.
6Pastinen T, Ratitio M, Lindroos K, et al. A system for specific : high- throughput genotyping by allele-specific primer extension on microarrays. Genome Res,2000 ; 10 : 1031 - 1042
7Boyles AL,Scott WK, Martin ER,et al. Linkage disequilibrium inflates type Ⅰ error rates in multipoint linkage analysis when parental genotypes are missing. Hum Hered ,2005 ;59:220 - 227
8Zhou X, Wong DT. Single nucleotide polymorphism mapping array assay. Methods Mol Biol,2007 ;396:295 - 314
9Lo KC, Bailey D, Burkhardt T, et al. Comprehensive analysis of loss of heterozygosity events in glioblastoma using the 100K SNP mapping arrays and comparison with copy number abnormalities defined by BAC array comparative genomic hybridization. Genes Chromosomes Cancer,2008 ;47:221 - 237
10Irving JA,Bloodworth L, Bown NP,et al. Loss of heterozygosity in childhood acute lymphoblastie leukemia detected by genome-wide mieroarray single nueleotide polymorphism analysis. Cancer Res, 2005 ;65:3053 -3058
