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哺乳动物胚胎基因组表达起始的调控 被引量:1

Regulation of zygotic gene activation at the beginning of mammalian development
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摘要 哺乳动物受精后 ,早期胚胎缺乏转录活性 ,早期发育由母源性的转录产物所调节。合子基因组激活的时期因物种而异。合子基因组激活可分为 2个时期 :起始阶段低水平的表达和第 2阶段爆发式的表达。在小鼠 1 细胞期胚 ,雌原核无转录活性 ,但雄原核出现基因转录。在 2 细胞早、中期之前 ,小鼠特异性基因的表达不需要增强子的作用 ,其启动子没有受到抑制 ,但由于基本转录因子的浓度较低 ,基因转录活性不高。基因高水平的转录发生在小鼠 2 细胞后期 ,此时转录抑制建立 ,特异性基因的转录依赖于增强子的作用。
出处 《畜牧与兽医》 北大核心 2003年第11期42-44,共3页 Animal Husbandry & Veterinary Medicine
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