摘要
目的 探讨HBV前C区 1896点突变的临床意义。方法 采用PCR ELISA检测技术 ,对 14 8例HBeAg阴性 ,HBV DNA阳性乙型肝炎病毒感染者HBV前C区 1896点突变基因分析 ,40例对照组 ,分成对照 1组和对照 2组 ,处理方法同实验组。结果 实验组中 69 8%HBV发生 1896点突变 ,对照 1组 5 %发生点突变 ,对照 2组无阳性。结论 HBeAg阴性不能认为无传染性及DNA复制 ,所以建议应同时检测HBV1896和HBV DNA。
Objective To study the clinical significance of 1896 dot mutation in HBV pre C Methods 1896 dot mutation was examined in 148 patients whith negative HBeAg and positive HBV DNA by PCR ELISA 40 cases of subjects were divided into two control groups and treated in the same way as the experiment group Results Experiment group had a positive rate of 69 8%;Control group Ⅰ had a positive rate of 5% and there was no positive rate in control group Ⅱ Conclusion Negative HBeAg may be infectious and cause DNA copy So,it is necessary to detect HBV 1896 and HBV DNA at the same time
出处
《四川医学》
CAS
2003年第11期1113-1114,共2页
Sichuan Medical Journal
关键词
乙肝病毒
点突变
hepatitis B
virus
dot mutation
