摘要
目的 :探讨口腔疣状癌超微结构特征 ,对疣状癌提出分型。方法 :取正常口腔黏膜 ,口腔疣状癌 ,口腔高分化鳞癌及低分化鳞癌石蜡标本各 8例 ,常规电镜制样 ,H -60 0型透射电镜检测。结果 :口腔疣状癌超微结构可归纳为 3种类型 :Ⅰ型 :癌上皮细胞分化较好 ,形态规则 ,细胞间隙略窄 ,细胞间有丰富且形态规则的桥粒 ,胞浆内线粒体少 ,但粗面内质网丰富 ,胞浆内未见桥粒。上皮间可见角化珠。Ⅱ型癌上皮细胞分化很差 ,细胞异形性明显 ,细胞间桥粒散在 ,细胞内桥粒丰富 ,包裹成团 ,粗面内质网少。Ⅲ型 :癌上皮细胞瘦长 ,核浆浓缩 ,细胞间隙较高分化鳞癌宽 ,细胞间桥粒瘦长且丰富。结论 :口腔疣状癌超微结构变化是其临床生物学行为多样性的基础 ,由此推测疣状癌自身可能存在不同的亚型和分化潜能。
Objective:To investigate the ultrastructure of oral verrucous carcinoma and then giving the classification of oral verrucous carcinoma according to the ultrastructural features .Method:Each of 8 cases of normal oral mucosa,oral verrucous carcinoma(VC),well differentiated squamous cell carcinoma(WDSCC) and poorly differentiated squamous cell carcinoma(PDSCC) was observed under H-600 electro-microscope.Result:Three ultrastructural types of VC were observed under the eletro-microscope:The first type has well-differentiated tumor cells with regular shape and cell gap.Abundant and regular desmosomes exist between the cells, but not in cytoplasm;however,abundant rough endoplasmic reticulums and few chondriosomes in cytoplasm.The second type has poorly differentiated tumor cell with evident heterotype.The desmosomes are scattered between the cells,but lumped in the cytoplasm.Few rough endoplasmic reticulums exist in the cytoplasm.The third type has leptosomic cells with concentrated cellular nuclear,cell gap wider than WDSCC.Conclusion:The different ultrostructural feature in VC is the base of clinic biological characteristics of VC.The different types and differentiation-degree might exist in VC.
出处
《临床口腔医学杂志》
2003年第11期673-675,共3页
Journal of Clinical Stomatology
基金
湖南省自然科学基金资助 (0 1JJY2 0 93)
关键词
口腔
疣状癌
超微结构
mouth
verrucous carcinoma
ultrastructure
