摘要
目的了解神经节细胞在先天性小肠闭锁中的分布情况,并探讨其临床意义。方法应用免疫组化技术检测15例先天性小肠闭锁患儿肠壁内NT-3的表达情况,并以正常小肠标本作为对照。结果肠闭锁组肠壁肌间神经丛中神经节细胞NT-3蛋白表达明显低于对照组(t'=9.90,P<0.05)。结论小肠闭锁近端肠壁内神经节细胞减少和神经干的变细可以影响闭锁区域肠道的功能,是病人术后肠道功能不良的原因所在。
Objective To evaluate the distribution of ganglia cells in congenital intestinal atresia and discuss the clinical significance.Methods Immunohistochemical analysis of NT-3protein in small bowel samples from patients with congenital intestinal atresia (n=15)and normal intestinal(n=6)was performed.Results The expression of NT-3protein in the myenteric plexuses neurons in small bowel atresia of sick children was significantly lower than those in the controls (t' =9.90,P<0.05).Conclusions The postoperative dysfunction of gut ,after primary anastomosis in intestinal atresia was related to decrease of ganglial cells and nerve trunk turned into thin in the myenteric plexus of intestinal wall.
出处
《临床小儿外科杂志》
CAS
2003年第3期178-181,共4页
Journal of Clinical Pediatric Surgery
