摘要
目的 建立氯诺昔康片溶出度测定方法。方法 选用中国药典 2 0 0 0年版溶出度测定第二法 ,紫外分光光度法检测。结果 测定波长为 376nm ,浓度在 0 .5～ 1 0 μg·ml-1 范围内 ,与吸收度呈良好的线性关系 (r =0 .9999) ,平均回收率为 1 0 0 .1 3% ,RSD 为 0 .6 8% ,每片溶出量应为标示量的 80 %以上。结论 本法适合于氯诺昔康片的溶出度测定。
Aim To develop a method of dissolution test for lornoxicam tablets.Methods Dissolution method Ⅱ of the Chinese Pharmacopoeia 2000 was used.UV spectrophotometry was adopted for the determination.Results Detection wave length was 376nm,the average recovery was 100.13%,RSD=0.68%.It had good linearity in the concentration range of 0.5～10μg·ml -1 ,r=0.999 9,the percentage of dissolution of lornoxicam in 45min were more than 80%.Conclusion This method could be applied to the determination of dissolution of lornoxicam tablets.
出处
《解放军药学学报》
CAS
2003年第5期382-383,共2页
Pharmaceutical Journal of Chinese People's Liberation Army
