摘要
目的 观察左旋氧氟沙星凝胶体外抗结核作用和支气管介入的安全性。方法 手工法、仪器法分别测定左旋氧氟沙星、左旋氧氟沙星凝胶的最小抑菌浓度和最小杀菌浓度及家兔经支气管介入的安全性试验。结果 左旋氧氟沙星凝胶对H3 7RV标准株、牛型结核分枝杆菌、草分枝杆菌MIC值分别为 0 .5、1、8mg·L-1 ,MBC值分别为 2、2、2 4mg·L-1 ;左旋氧氟沙星凝胶与左旋氧氟沙星单体MIC、MBC值无显著差异 ;动物安全性试验阴性。结论 左旋氧氟沙星凝胶具有与左旋氧氟沙星单体相同的抗结核菌药效 ,卡波姆基质不影响左旋氧氟沙星的抗菌活性 ;
Aim To observe the activity of levofloxacin gel against Mycobacterium tuberculosis in vitro and its security in bronchia interventional therapy.Methods The MIC and MBC of levofloxacin and levofloxacin gel were measured by handwork method and instrument method,the security of levofloxacin gel was assessed by bronchia interventional therapy using rabbits as experiment animals.Results The MIC of levofloxacin gel to M.Tuberculosis H 37 RV,M.bovis and M.phlei are 0.5,1,8mg·L -1 respectively.The MBC of levofloxacin gel to M.tuberculosis H 37 RV,M.bovis and M.phlei are 2,2,24mg·L -1 respectively.The MIC and MBC of levofloxacin gel and levofloxacin have no significant difference.The animal security experiment is negative.Conclusion These results suggest that levofloxacin gel and levofloxacin have the same efficacy against Mycobacterium tuberculosis and carbomer doesn't affect the activity of levofloxacin against Mycobacterium tuberculosis.Levofloxacin gel which contains carbomer is safe in bronchia interventional therapy.
出处
《解放军药学学报》
CAS
2003年第5期338-340,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
国家"十五"科技攻关基金课题 No .2 0 0 1BA70 5B0 4
