摘要
目的 :探讨细胞增殖抗原Ki- 6 7在喉癌组织中的表达及临床意义。方法 :采用免疫组织化学S -P法检测 4 1例喉癌组织中Ki- 6 7的表达 ,并与 12例癌旁正常组织作对照 ,进行分析比较。结果 :4 1例喉癌组织中Ki - 6 7的阳性表达率为5 3.6 % ,12例癌旁正常组织阳性表达率为 16 .7% ,二者具有显著性差异 (P <0 .0 5 )。Ki- 6 7的阳性表达率与喉癌病人的不同性别、年龄、病程、肿瘤部位和TNM分期无关 (P >0 .0 5 ) ,但与吸烟、饮酒、淋巴结有无转移以及喉癌组织的病理分级之间具有显著性差异 (P <0 .0 5 ,P <0 .0 1)。结论 :Ki- 6 7在喉癌的发生发展中起一定的作用 ,可作为判断喉癌恶性程度和预后的重要参考指标。
Objective:To determine clinical significance and expression of cellular proliferative antigen Ki-67 in laryngeal carcinoma tissues.Methods:Ki-67 expressions in 41 cases of laryngeal carcinoma tissues were detected by immunohistochemical S-P method;12 cases of pericarcinoma tissues were used as control and comparison.Results:The positive expression rate of Ki-67 was 53.6% in 41 cases of laryngeal carcinoma tissues and 16.7% in 12 cases of pericarcinoma tissues,which showed significant difference ( P <0.05).There was no significant difference in sex,age,course,tumor site and TNM stage.The levels of Ki-67 expression were significantly higher in the groups with smoking, drinking habits and lymph node metastasis than in those without ( P <0.05).The positive expression rate of Ki-67 showed significant difference among pathological stages of laryngeal carcinoma tissues ( P <0.01).Conclusion:The results suggest that the Ki-67 might play an important role in the development and progression of laryngeal carcinoma and should be used as an important reference marker of malignant degree and prognosis of laryngeal carcinoma.
出处
《重庆医科大学学报》
CAS
CSCD
2003年第5期573-575,579,共4页
Journal of Chongqing Medical University
关键词
喉癌
KI-67
免疫组织化学
Laryngeal carcinoma
Ki-67
Immunohistochemistry
