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不同剂量静脉注射免疫球蛋白辅助治疗狼疮性肾炎临床观察 被引量:2

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摘要 目的 :观察不同剂量静脉注射免疫球蛋白 (IVIG)辅助治疗狼疮性肾炎 (LN )的疗效。方法 :67例LN患者随机分成A、B、C3组进行治疗 ,3组均同样使用激素和环磷酰胺 (CTX) ,B组联用大剂量IVIG治疗 ,C组联用中小剂量IVIG治疗 ;对比不同治疗方案对SLE疾病活动指数 (SLEDAI)、尿蛋白及院内感染情况的影响。结果 :B、C组在降低SLEDAI、降低尿蛋白、降低院内感染方面明显优于A组 (P <0 0 5 ) ,而B、C两组间差异无显著性 (P >0 0 5 )。结论 :IVIG辅助治疗LN ,不论是使用大剂量还是中小剂量 。
出处 《临床医学》 CAS 2003年第10期50-51,共2页 Clinical Medicine
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  • 1李广然,叶任高.狼疮肾炎的活动指标[J].新医学,1998,29(11):607-608. 被引量:20
  • 2麦慈光,张道友,叶任高.90例系统性红斑狼疮患者死亡原因分析[J].中华肾脏病杂志,1998,14(2):114-116. 被引量:25
  • 3Ballow M. Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory diseases. J Allergy Clin Immunol, 1997,100(2) : 151-157.
  • 4Brand A,Vuist WM,Vanschaik IM. In vitro investigation of immunoglobulin treatment mechanism in autoimmune diseases. Clin Exp Rheumatol, 1996,14 ( Suppl 15) : 27 - 30.
  • 5Silvestris F, D Amore O, Cafforio P, et al. Intravenous immune globulin therapy of lupus nephritis:use of pathogenic anti-DNA-reactive IaG. Clin Exp Immunol.1996.104(Suppl 1) :91-97.

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  • 1Negi VS, Elluru S, Siberil S, et al. Intravenous immunoglobulin: An update on the clinical use and mechanisms of action. J Clin Immunol, 2007, 27(3), 233-245.
  • 2Bayry J, Lacroix-Desmazes S, Delignat S, et al. Intravenous immunoglobulin abrogates dendritic cell differentiation induced by interferon-alpha present in serum from patients with systemic lupus erythematosus. Arthritis Rheum, 2003, 48(12): 3497-3502.
  • 3Su K, Yang H, Li X, et al. Expression profile of FcyRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol, 2007, 178(5): 3272-3280.
  • 4Zandman Goddard G, Blank M, Shoenfeld Y. Intravenous immunoglobulins in systemic lupus erythematosus: from the bench to the bedside. Lupus, 2009, 18(10): 884-888.
  • 5Ephrem A, Chamat S, Miquel C, et al. Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis. Blood, 2008, 111(2): 715-722.
  • 6熊思东.免疫球蛋白.见:金伯泉,主编.医学免疫学.第5版.北京:人民卫生出版社,2008:41-48.
  • 7Perricone R, De-Carolis C, Kroegler B, et al. Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion. Rheumatology, 2008, 47(5), 646-651.
  • 8Karim MY, Pisoni CN, Khamashta MA. Update on immunotherapy for systemic lupus erythematosus--what's hot and what's notl Rheumatology, 2009, 48(4), 332-341.
  • 9Ephrem A, Misra N, Hassan G, et al. Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin. Clin Exp Med, 2005, 5(4): 135-140.
  • 10Boletis JN, Ioannidis JP, Boki KA, et al. Intravenous immunoglobulin compared with cyclophosphamide for proliferative lupus nephritis. Lancet, 1999, 354(9178): 569-570.

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