摘要
目的:探讨人类胚胎脑动脉分叉部弹力纤维和中层平滑肌细胞(Smoothmusclecell,SMC)的构筑发育过程及特点,以助对脑动脉瘤病因假说的理解和验证。方法:收集胎龄12～28周人类胚胎共17例,每1个周龄取1例,男女不限。对胎脑Willis环周围的动脉分叉部行不同方向组织切片,观察弹力纤维和中层SMC的构筑发育过程。结果:胎脑Willis环周各动脉弹力纤维在1.5～12.6层之间,弹力纤维在同一切片有紊乱和逐渐减少现象,内弹力层第19周发育完整;中层SMC在1.1～9.0层之间,70.6%的胎脑动脉个别分叉部发现中层SMC缺陷,所取标本的30.3%发现中层SMC缺陷。结论:胎脑动脉内弹力纤维和中层SMC随胎龄增长而增多,内弹力层于第13～19周出现并发育成熟,脑动脉分叉部存在先天性SMC缺陷、弹力纤维紊乱和逐渐减少现象,有助于对脑动脉瘤病因假说的理解和验证。
AIM:To explore the developmental characteristics of the elastic fibers and med ial smooth muscle cells (SMCs) at the bifurcations of human fetal intracranial a rteries so as to verify the etiological hypothesis of cerebral aneurysm. METHODS:From 17 normal fetuses aged 12 to 28 weeks old, the segments of the Wi llis' arteries (including the bifurcations) were harvested and cut into sections in 1 of the 3 orthogonal planes.The 3-dimensional structures of the elastic fi bers and SMCs were observed microscopically. RESULTS:The number of the layers of the elastic fibers and medial SMCs of the Willis' artery bifurcations were 1.5 to 12.6 and 1.1 and 9.0 respectively.Local defects of the medial SMCs at the bifurcations of the developing arteries were f ound in 70.6%of the fetuses and 30.3%of the specimen.
出处
《中国临床康复》
CSCD
2003年第25期3466-3467,F003,共3页
Chinese Journal of Clinical Rehabilitation
关键词
脑动脉瘤
发病原因
胚胎
脑动脉
弹力纤维
中层平滑肌细胞
The number of the layers of the elastic fibers and medial SMCs in f etal brain arteries increases with growth, and the inner elastic layer appears a nd matures at 13-19 weeks.The congenital defect of the elastic fibers and SMCs observed in this
