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2-(1-咪唑基)乙酸的新法合成 被引量:6

Synthesis of 2-(1-Imidazolyl)acetic Acid
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摘要 Imidazolyl)acetic acid was prepared from imidazole by alkylation with ethyl chloroacetate and hydrolysis in one pot with an overall yield of 71.9%. Imidazolyl)acetic acid was prepared from imidazole by alkylation with ethyl chloroacetate and hydrolysis in one pot with an overall yield of 71.9%.
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2003年第10期494-494,共1页 Chinese Journal of Pharmaceuticals
基金 国家自然科学基金 ( 3 0 0 80 0 0 3 )
关键词 唑来膦酸 治疗 肿瘤 1-咪唑基 2-乙酸 乙酸乙酯 高血钙症 恶性骨转移瘤 2-(1-咪唑基)乙酸 合成 imidazolyl)acetic acid zoledronic acid intermediate synthesis
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参考文献3

  • 1王磊,孙兴华.用KOH/Al_2O_3合成N-烷基咪唑[J].应用化学,1993,10(4):84-85. 被引量:15
  • 2Lopez P, Zaderenko P, Balcazar JL, et al. The zwitterion structure of imidazol-1-ylacetic acids in the solid state and in solution[J]. J Mol Struct, 1996,377(2) :105-112.
  • 3Kamijo T, Yamamoto R, Harada H, et al. An Improved and convenient procedure for the synthesis of 1-substituted imldazoles[J]. Chem Pharm Bull, 1983,31(4):1213-1221.

二级参考文献2

  • 1王进贤,高等学校化学学报,1985年,6卷,10期,913页
  • 2刘汉明,有机化学,1983年,3卷,3期,123页

共引文献14

同被引文献38

  • 1蒋晔,张晓青,徐智儒.唑来膦酸的合成[J].华西药学杂志,2005,20(1):29-30. 被引量:8
  • 2王磊,孙兴华.用KOH/Al_2O_3合成N-烷基咪唑[J].应用化学,1993,10(4):84-85. 被引量:15
  • 3李以欣.成年病治疗药开发概况[J].国外医药(合成药.生化药.制剂分册),1994,15(6):323-327. 被引量:2
  • 4陈宝泉,李彩文,雷英杰,欧阳杰.2-(1-咪唑基)-乙酸的合成工艺改进[J].精细石油化工,2007,24(2):16-18. 被引量:5
  • 5方东,施群荣,巩凯,刘祖亮.咪唑型室温离子液体的绿色合成研究[J].化学试剂,2007,29(1):4-6. 被引量:34
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  • 7Aronhime, Judith, Lifshitz L, et al. Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation [P]. US: 7,435,827.
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