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运动神经元生存蛋白及其相互作用蛋白研究进展 被引量：2

Advance in researches on survival of motor neurons protein and its interaction proteins
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摘要 运动神经元生存蛋白 (survival of motor neurons,SMN)是脊肌萎缩症的基因产物。目前对SMN蛋白的功能研究已成为探讨脊肌萎缩症发病机理的热点。本文就 SMN蛋白的结构。 Survival of motor neurons (SMN) protein is the product of spinal muscular atrophy (SMA) gene. Now the function researching of SMN protein has become hotspot field to discuss the pathogenic mechanism of SMA. The construction, distribution and function of SMN protein are reviewed in this paper.
作者 吴志国 杨晓苏 肖波
机构地区 中南大学湘雅医院神经内科
出处 《中华医学遗传学杂志》 EI CAS CSCD 2003年第5期430-432,共3页 Chinese Journal of Medical Genetics
基金 国家自然科学基金(30 1 70 330 )
关键词 运动神经元生存蛋白 脊肌萎缩症 SMN SMA 氨基酸 运动神经元 Genes Neurology Pathology Proteins
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献24

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同被引文献33

  • 1马华智,吴纯启,廖明阳.羟基脲的非临床分子毒理学研究进展[J].癌变·畸变·突变,2004,16(5):318-320. 被引量：5
  • 2王楠,阎征,刘娜.组蛋白去乙酰酶抑制剂的药理学研究进展[J].中国新药杂志,2004,13(7):594-598. 被引量：2
  • 3唐丽琴,魏伟.组蛋白去乙酰化酶抑制剂与炎症免疫性疾病[J].中国药理学通报,2007,23(1):1-4. 被引量：5
  • 4王洁,王治平.儿童脊肌萎缩症诊治新进展[J].诊断学理论与实践,2007,6(3):281-283. 被引量：2
  • 5Mitchell RL,Ching HW.Spinal muscular atrophy[J].The Lancet,2008,71(9630):2121-2133.
  • 6Alea D,Erkan O,Christion LL.A negatively acting bifunction RNA increase survival motor neuron both in vitro and in vivo[J].Human Gene Therapy,2008,19(11):1307-1315.
  • 7Dimatteo D,Calahan S,Kmiec EB.Genetic conversion of an SMN2 gene to SMN1:a novel approach to the treatment of spinal muscular atrophy[J].Exper Cell Res,2008,314:878-886.
  • 8Lisziewicz J,Foli A,Lori WM.Hydroxyurea in the treatment of HIV infection:clinical efficacy and safety concerns[J].Drug Sa,2003,26(9):605-624.
  • 9Chung YY,Hui HL,Ya SC,et al.5-(N-ethy-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells[J].Ann Neurol,2008,63:26-34.
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中华医学遗传学杂志
2003年 第5期

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