摘要
目的:探讨米索前列醇(简称米索)防治产后出血的效果。方法:选择正常单胎足月妊娠阴道分娩者262例,随机分为米索组(85例)于胎儿娩出后立即给予米索400μg舌下含服;米索加缩宫素组(90例)于胎儿娩出后含服米索400μg及肌肉注射和静脉滴注缩宫素各10 IU;缩宫素组(87例)于胎儿娩出后立即肌肉注射缩宫素10 IU,静脉滴注缩宫素10 IU。观察各组产后2 h内出血量(ml)、产后出血发生率(％)、第3产程时间(min)及血压(mmHg)的变化。结果:平均出血量、产后出血发生率及第3产程时间米索组为(221±55)ml、2/85例(2.35％)、(6.2±3.0)min;米索加缩宫素组为(214±49)ml、2/90例(2.22％)、(5.8±3.3)min;缩宫素组为(278±56)ml、13/87例(14.94％)、(8.7±4.0)min。米索组与缩宫素组比较,2h内出血量、产后出血发生率。以及第3产程时间3项指标差异均有显著性(P<0、01、P<0.01、P<0.05),米索组与米索加缩宫素组比较,上述3项指标差异均无显著性(P>0.05)。米索组、米索加缩宫素组及缩宫素组收缩压和舒张压分别为:(124±14)、(121±18)、(123±13)mmHg(1 mmHg=0.133kpa);(70±11)、(68±9)、(68±13)mmHg,3组之间每2组相互比较差异均无显著性(P>0.05)。结论:含服米索前列醇促进子宫收缩作用强于缩宫素,能有效减少产后出血量。
objective:To observe the efficacy of misopristol on preventing postpartum bleeding. Methods:Two hundred and sixty-two puerperant patients in term pregnancy were randomized into three groups: misoprostol group (n = 85), 400 u,g misoprostol was given orally immediately after parturition; misoprostol plus oxytocin group ( n = 90), 400 pig misoprostol was given orally and 10 IU oxytocin was injected into muscle and 10 IU intravenously administrated immediately after parturition; oxytocin group ( n = 87), 10 IU oxytocin was injected into muscle and 10 IU intravenously administrated immediately after parturition. The amount of bleeding of 2 hours just after parturition, the rate of puerperant bleeding, the duration of third stage of labour and blood pressare were recorded in above three groups. Results: The mean amount of bleeding, the rate of postpartum hemorrhage and the duration of third stage of labor in misoprostol group were (221 +55)ml, 2. 35% and (6. 2 +3. 0)minutes, in misoprostol proup were (214 +49)ml, 2. 22% and (5. 8 +3. 3) minutes, and in oxytocin group were(278+56) ml, 14.94% and (8. 7 +4.0) minutes, respectively. There were significant differences between misoprostol group and oxytocin group ( P < 0. 01 or P < 0. 05), there were no differences between misoprostol group and misoprostol plus oxytocin group. Conclusion: Misoprostol is more effective on preventing puerperant bleeding than oxytocin.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2003年第6期613-614,637,共3页
Journal of Nanjing Medical University(Natural Sciences)
关键词
产后出血
米索前列醇
缩宫素
postpartum hemorrhage
misoprostol
oxytocin
