摘要
目的 探讨用亲属供脾行脾移植治疗血友病甲的围手术期处理。方法 分析我院施行的 5例亲属供脾脾移植术治疗血友病甲的围手术期循环系统、凝血系统及脾功监测和排斥反应 ,以及并发症的处理经验。结果 除 1例术后 3 8d死于脑水肿外 ,其余均安然度过围手术期。血中因子VIII凝固活性部分 (VIII :C)浓度于术后 5～ 7d开始升高 ,升高 15 %～ 5 6%。脾脏有功能存活最短 1个月 ,最长者已逾 3年。结论 对循环系统、凝血系统及脾脏功能严密地监护和及时。
Objective To investigate the perioperative treatment of the living relative spleen transplantation for patients with severe hemophilia A. Methods The experiences of surveillance of circulation system , coagulation system ,the function and rejection of transplanted spleen on 5 patients were analyzed. Results 4 recipients alived well after operation,but one died of hydrocephalus on the 38th postoperative day. The concentration of Ⅷ:C in serum rose begining on 5th～7th postoperative day, and rose to 18%～56% . The function of the transplanted spleen in 4 alived patients was still well for 1 month to >3 years. Conclusions Surveillance of circulation system, coagulation system and transplanted splenic function,and correct perioperative treatment are the key points for getting the success of spleen transplantation.
出处
《中国普通外科杂志》
CAS
CSCD
2003年第10期772-774,共3页
China Journal of General Surgery
关键词
脾移植
血友病/治疗
围手术期
SPLEEN TRANSALANTATION
HEMDPHILIA/ther
PERIOPERATION
