摘要
采用四氯化碳、高脂低蛋白膳食、饮酒等复合病因刺激复制肝硬变动物模型,在肝硬变形成后,经茯苓醇治疗三周,结果表明对照组动物仍有肝硬变,而给药组动物肝硬变明显减轻,肝内胶原蛋白含量低于对照组,而尿羟脯氨酸排出量高于对照组,表明药物可促进实验性肝硬变动物肝脏胶原蛋白降解,使肝内纤维组织重吸收。
The therapeutic actions of Poria cocos on experimental liver cirrhosis induced by carbon tetraehloride and dietetic injury have been studied. Results showed that after three week's treatment with Poria cocosi, hepatic fibrosis markedly lessened,collagen contents in the liver became significantly lower and urinary hydroxyproline contents strikingly higher than these of the cirrhotic control group. These results indicated that Poria coces exerts collagenolytic and collagen resorptive effects on liver cirrhosis in rats.
关键词
痉脯氨酸
茯苓
肝硬变
Liver cirrhosis, Hydroxyproline, Poria coces
