摘要
目的 进一步探讨血清总胆汁酸 (TBA)评估慢性重型肝炎患者肝细胞损伤程度及其预后的临床价值。方法 对慢性重型肝炎组 12 2例、慢性肝炎组 98例和正常对照组 4 8人同时测定TBA、总胆红素 (TBIL)及凝血酶原活动度 (PA) ,并分析它们之间的关系。结果 慢性重型肝炎患者血清TBA水平显著高于慢性肝炎组及正常对照组 (P <0 .0 1) ,TBA与TBIL呈正相关 ,与PA呈负相关 (分别为r =0 .712 ,P <0 .0 1;r =- 0 .832 ,P <0 .0 1) ;治愈 +好转组TBA明显低于恶化 +死亡组 (P <0 .0 1)。结论 慢性重型肝炎TBA显著升高 ,肝细胞损伤越严重 ,TBA水平越高。TBA是敏感的肝功能检测指标 ,对慢性重型肝炎的疗效及预后评估有一定的临床价值。
Objective To investigate the significance of serum TBA in chronic severe hepatitis. Methods One hundred and twenty two cases with chronic severe hepatitis, 98 cases with chronic hepatitis and 48 cases in control group, were included in the study. Serum TBA,TBIL (total bilirabine),PA (prothrombin activity) were tested. Results The level of TBA in chronic severe hepatitis was higher than that in other groups( P <0.01), the change of TBA in chronic severe hepatitis was parallel with TBIL and contrary to PA ( P <0.01). Conclusion TBA is higher greatly in chronic severe hepatitis groups, and the change of serum TBA can be used to judge the clinical effect and prognosis of chronic severe hepatitis.
出处
《苏州大学学报（医学版）》
CAS
2003年第5期565-566,共2页
Suzhou University Journal of Medical Science
关键词
总胆汁酸
慢性重型肝炎
total bile acid
chronic severe hepatitis
