摘要
目的 :探讨一氧化氮 (NO)及超氧化物歧化酶 (SOD)在口腔扁平苔藓 (OLP)发病中的作用。方法 :选择OLP患者 30例 (其中糜烂型 12例 ,非糜烂型 18例 )及健康献血员 30例 ,分别采集组织标本和血清标本 ,检测NO含量 (硝酸还原酶法 )和SOD活性 (黄嘌呤氧化酶法 ) ,所得数据采用配对t检验进行统计学处理。结果 :组织与血清中NO值 ,OLP组均高于正常对照组 (P <0 .0 5 ) ,糜烂型虽高于非糜烂型 ,但无统计学差异 (P >0 .0 5 ) ;组织与血清中SOD值 ,OLP组均明显低于正常对照组 (P <0 .0 1) ;而糜烂型与非糜烂型比较 ,SOD值均下降 ,但血清中SOD值差异不显著 (P >0 .0 5 )。结论 :在OLP发病的不同阶段 ,NO含量及SOD活性呈动态变化 ,随着病变程度加重 ,NO含量明显升高 ,SOD活性明显下降 ,导致局部组织免疫反应异常 ,二者可能发挥协同作用 ,参与OLP的发病。
Objective:To study the role of nitric oxide(NO) and superoxide dismutase(SOD) in oral lichen planus(OLP).Method:30 OLP patients and 30 healthy donors (control group) were involved in this study.NO level and SOD activity in tissues and serums were measured respectively.Result:NO level in OLP group was higher than control group(P< 0.05),but,there was no significant difference between erosion type and non-erosion type(P> 0.05).SOD activity in OLP group was significantly lower than control group(P< 0.01),but there was no significant difference in serum between erosion type and non-erosion type(P> 0.05).Conclusion:NO level and SOD activity were changed dynamically in different developmental stage of OLP.The lower SOD activity and higher NO level may cooperate and thus lead to prolonged course of OLP.
出处
《临床口腔医学杂志》
2003年第10期624-625,共2页
Journal of Clinical Stomatology
