摘要
目的:明确乳腺癌雌激素诱导基因PS2/TFFl在胃癌及癌前病变中的表达及其意义。方法:采用免疫组织化学方法测定121例患者(慢性浅表性胃炎20例、胃溃疡20例、不典型增生20例、不完全肠化生20例、完全肠化生21例及胃癌20例)及20名健康志愿者胃黏膜组织中PS2/TFF1蛋白的表达。结果:PS2/TFF1在慢性浅表性胃炎、胃溃疡中表达与对照组比较明显增加(慢性胃炎组 vs正常对照组P<0.01 q=7.721胃溃疡组 vs正常对照组 P<0.01 q=5.256),在不典型增生、不完全肠化生及胃癌中表达比对照组明显减低(不典型增生组 vs正常对照组P<0.01 q=8.051;不完全肠化生组 vs正常对照组P<0.01,q=11.356;胃癌组 vs正常对照组P<0.01q=8.238),在完全肠化生组PS2/TFF1表达无明显增高(20/21,95.24％),与不完全肠化生组表达(11/20,55％)相比差异显著(P<0.01 x^2=8.994)。结论:(1)PS2/TFF1蛋白在胃黏膜保护中可能起重要作用;(2)PS2/TFF1的表达缺失可能是胃肿瘤恶性转化过程中的早期事件。
AIM: To determine the significance of PS2/TFF1 protein expression in chronic superficial gastritis (CSG), gastric ulcer (GU),gastric mucosal intestinal metaplasia (IM), gas- tric mucosal dysplasia and gastric cancer(GC). METHODS: Pathologic specimens of 121 patients with gas- tric mucosal diseases and 20 healthy volunteers were immunostained for PS2/TFF1. RESULTS: Positive PS2/TFF1 staining was seen throughout all epithelia with normal gastric mucosas, CSG, GU and in complete type of intestinal metaplasia (20/21). On the contrary, 11 of 20 incomplete type of intestinal metaplasia had positive staining (P<0.01). The expressions of PS2/ TFF1 protein in CSG and GU were significantly higher than that in control group (P<0.01), while the expressions of PS2/TFF1 protein in IM,gastric mucosal dysplasia and GC were obviously lower than that in control group (P<0.01). CONCLUSION: Our results indicate that PS2/TFF1 may play an important role in gastric mucosal protection,and loss of PS2/TFF1 expression may occur as an early event in the malignant transformation process of intestinal-type tumors.
出处
《世界华人消化杂志》
CAS
2003年第9期1302-1305,共4页
World Chinese Journal of Digestology
