摘要
目的:改进糠酸莫美松的合成路线。方法:以合成莫美他松的中间体21-氯-17α-羟基-16α-甲基孕甾-1,4,9(11)-三烯-3,20-二酮为原料,经9,11-氯羟化、17-糠酰化两步反应,制得目标化合物糠酸莫美松。结果:用上述两步反应制备糠酸莫美松的合成路线同已有的老工艺相比,简化了操作,提高了收率,总收率达到55％。结论:该合成方法的研究对促进糠酸莫美松的工业化生产可起到积极作用。
Objective:To study on synthesis of Mometasone Furcate. Methods:21 - chloro - 17a - hydroxyl -16a-methylpregna - A1,4,9(11) -triene-3,20 - dione was used as raw material, Mometasone Furoate was synthesized by two steps of 9,11 - chlorohydroxylation and preparation of 17 - furcate. Results;Compared with the traditional procedure, the method metioned in this article was more simple in operation, and highter yield (55% ) was obtained. Conclu-Sion; This method of synthesis method possesses an affirmative effect on the industrialized production of Mometasone Furoate.
出处
《上海医药》
CAS
2003年第10期471-472,共2页
Shanghai Medical & Pharmaceutical Journal
