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内毒素耐受性与TLR4信号通路 被引量：5

Relationships between LPS-tolerance and TLR4 as well as its signaling pathway
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摘要 内毒素 (lipopolysaccharide ,LPS)耐受性普遍存在 ,并与其他病原微生物致病因子 (LAM、STF等 )存在交叉耐受性。不同种类LPS产生耐受性的可能性与机制不同。TLR4作为LPS靶细胞膜上的跨膜受体 ,主要介导LPS信号的跨膜转导 ,TLR4结构与功能的改变 ,以及TLR4信号通路中各个环节 (MD2、MyD88、IRAK、IκB、NF κB、炎症因子 )的功能缺陷 。
作者 张德明 毛宝龄
机构地区 第三军医大学新桥医院全军呼吸内科中心
出处 《生理科学进展》 CAS CSCD 北大核心 2003年第3期277-279,共3页 Progress in Physiological Sciences
基金 国家自然科学基金重点资助课题 (39730 2 10 )
关键词 内毒素 耐受性 信号通路 信号转导
分类号 Q257 [生物学—细胞生物学] R392 [医药卫生—免疫学]
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参考文献10

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同被引文献54

  • 1韩德五.肠源性内毒素血症是肝炎、肝病的危险因素[J].山西医科大学学报,2006,37(1):1-4. 被引量：39
  • 2华静,邱德凯,李继强,李恩灵,彭延申.Toll样受体4在CCl_4诱导的大鼠慢性肝损伤过程中的表达[J].胃肠病学,2006,11(2):87-91. 被引量：7
  • 3孙晓东,周志伟,万德森,王国强,方淯靖,卢震海,陈功.小鼠肝枯否细胞的分离、培养与鉴定[J].中国现代医生,2007,45(06X):22-23. 被引量：9
  • 4Qureshi ST,Lariviere L,Leveque G,et al.Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)[J].J Exp Med,1999,189(4):615-625.
  • 5Qin L,Li G,Qian X,et al.Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation[J].Glia,2005,52(1):78-84.
  • 6Safadi R,Friedman SL.Hepatic fibrosis--role of hepatic stellate cell activation[J].Medscape Genneral Medicine,2002,4(3):27.
  • 7Spruss A,Kanuri G,Wagnerberger S,et al.Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice[J].Hepatology.2009,50(4):1004-1006.
  • 8Hironaka K,Sakaida I,Uchida K,et al.Correlation between stellate cell activation and serum fibrosis markers in choline-deficient L-amino acid-defined diet-induced rat liver fibrosis[J].Dig Dis Sci,2000,45(10):1935-1943.
  • 9Poltorak A,He X,Smirnova I,et al.Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:mutations in Tlr4 gene[J].Science,1998,282(5396):2085-2088.
  • 10Schafer C,Schips I,Landig J,et al.Tumor-necrosis-factor and interleukin-6 response of peripheral blood monocytes to low concentrations of lipopolysaccharide in patients with alcoholic liver disease[J].Z Gastroenterol,1995,33(9):503-508.

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生理科学进展
2003年 第3期

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