摘要
应用免疫组化技术对168例乳腺病变的基膜特异性抗原层粘连蛋白和Ⅳ型胶原进行定位检测。结果:乳腺良性病变和导管内癌的基膜为连续细线状;导管癌早期浸润区局部基膜呈碎颗粒状或完全消失;大部分浸润癌的癌巢周边无基膜,少部分有染色较弱的不连续线状或颗粒状基膜物质围绕。统计结果表明,乳腺癌的基膜表达能力与肿瘤的组织学分级有关(P<0.025),与肿瘤的大小、临床分期、腋窝淋巴结转移及预后无关(P皆>0.05)。
The immunohistochemical technique was used in the detec-tion of specific components of basement membrane;laminin and type Ⅳ colla-gen,in 168 cases of breast lesion.The results showed that the BM was con-
tinuous and linear in benign lesion and intraductal carcinoma.The conti-nuity of BM was broken in case of early invasion.The complete or fragmental BM was seen surrounding nests of infiltrating carcinoma in some ases.Statisti-
cally,the formation of BM was correlated with differentiation of the tumor (P<0.025)but not with ize,staging,metastasis and prognosis(P■0.05).Broken of BM as a maker of early invasion was therefore justifiable and presence of BM enclosing infiltrating tumor nest was an indicator of better differentiation of the tumor.
出处
《山东医科大学学报》
1992年第1期42-44,共3页
Acta Academiae Medicinae Shandong
关键词
乳腺肿瘤
癌
基膜
病理学
胶原
Breast neoplasms
Carcinoma,ductal
Basement membrane
Immunohistochemistry
Pathology
