摘要
目的 探讨大肠杆菌在小儿下呼吸道感染痰液中的分离情况及耐药特征。方法 连续 12个月对下呼吸道感染患儿常规进行深部痰液培养 ,用细菌自动鉴定系统进行菌株鉴定和抗生素敏感试验。结果 分离大肠杆菌 16 9株 ,分离率为 3.99% ,在病原菌阳性的病例中占 14 .31%。 <1岁患儿大肠杆菌分离率显著高于 1岁以上者 (χ2 =4 1.73,P <0 0 0 1)。大肠杆菌产生超广谱 β内酰胺酶率 (ESBL)为 4 2 .6 0 % ,对 β内酰胺类抗生素的耐药率较高 ,对阿莫西林 /棒酸、头孢哌酮 /他巴唑坦的耐药率分别为 10 .6 5 %和 2 .38%。菌株对呋喃妥因和立克菌星的敏感率高达 92 .31%和 84 .2 5 %。所有的菌株都对亚胺培南敏感。结论 大肠杆菌是小儿下呼吸道感染的常见致病菌 ,产生ESBL率高 ,对重症感染的治疗 。
Objective To investigate the isolations of Escherichia coli from sputum in children with low respiratory tract infection and the antibiotics\|resistance of these organisms in Hangzhou.Methods Sputum specimens were collected from children with low respiratory tract infection in 12 consecutive months, and Escherichia coli isolates were identified with GNI card of Vitek system. Antibiotics sensitivity tests were performed by Vitek system with GNS\|506 or GNS\|121 card in vitro.Results One hundred and sixty\|nine Escherichia coli strains (isolating rate was 3.99%) were isolated from 4238 patients and the ratio was 14.31% in 1181 bacteria\|positive cases. The isolation rate in children whose ages were not more than 1 year was statistically significant higher than that in children whose ages were more than 1 year old(\%χ\+2=41.73,P\%<0.001). Rate of ESBL\|positive strains was 42.60% and resistance to β\|lactam antibiotics was high. Of all 169 strains, 10.65% and 2.38% of strains were resistant to amoxicillin/clavulanic acid and cefoperazone/sulbactan, while100%, 92.31% and 84.25% of strains were sensitive to imipenem, furatuorin and netromycin respectively.Conclusion Escherichia coli was a common cause of respiratory tract infection in children especially in children who were not more than 1 year old, and rate of ESBL\|positive strains was high. Imipenem could be considered as the most active antibiotic in treating serious infections due to these organisms.
出处
《杭州医学高等专科学校学报》
CAS
2003年第5期255-257,共3页
Journal of Hangzhou Medical College
关键词
儿童
大肠杆菌
下呼吸道感染
children
Escherichia coli
low respiratory tract infection
