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N-(4-甲氧基-3-甲酰基苄基)亚氨基二乙酸的合成及表征 被引量：2

SYNTHESIS AND CHARACTERIZATION OF N-(4-METHOXYL -3-FORMYLBENZYL)IMINODIACETIC ACID
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摘要 以 2 -甲氧基苯甲醛为原料 ,与浓盐酸和 4 0 %甲醛溶液进行氯甲基化反应 ,再用新制的无水碳酸钾作质子吸收剂、干燥的乙腈作溶剂 ,和亚氨基二乙酸二乙酯发生N_烷基化反应 .然后用饱和Ba(OH) 2 水溶液进行水解得到N_(4_甲氧基_3_甲酰基苄基 )亚氨基二乙酸的钡盐沉淀 ,最后用稀硫酸处理得到产物 .通过改变各种实验因素 ,找到了合成标题化合物的最佳实验条件 .该方法工艺简单、产率较高 . N_(4_Methoxyl_3_formylbenzyl)iminodiacetic acid was synthesized from 2_methoxylbenzaldehyde in the sequence of a chloromethylation by formaldehyde a nd concentrated HCl, in dry acetonitrile an amination by diethyl iminodiacetate using anhydrous potassium carbonate as a proton absorbent, a hydrolysis by satur ated hydrated baryta solution and a treatment with dilute sulfuric acid. The rea ction conditions involved in the synthetic route were studied and the structure of the title compound was characterized by elemental analysis and 1H NMR s pectra.
作者 谢怡 陈默 高根之 岳明波
机构地区 曲阜师范大学化学科学学院
出处 《曲阜师范大学学报（自然科学版）》 CAS 2003年第4期82-84,共3页 Journal of Qufu Normal University(Natural Science)
关键词 N-(4-甲氧基-3-甲酰基苄基)亚氨基二乙酸 合成 2-甲氧基苯甲醛 氯甲基化反应 结构表征 N-(4-Methoxyl-3-formylbenzyl)iminodiacetic acid synthesis chlorome thylation hydrolysis
分类号 O625.636 [理学—有机化学]
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参考文献9

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二级参考文献1

  • 1王芹珠，有机化学，1997年，342页

共引文献2

同被引文献17

  • 1宋宏涛,魏洪源,罗顺忠,楚士晋.N_2S_2类双功能联接剂前体的合成研究[J].西南科技大学学报,2006,21(3):27-30. 被引量：3
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曲阜师范大学学报（自然科学版）
2003年 第4期

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