摘要
目的 探讨 β1肾上腺能受体 (以下简称 β1受体 )基因Ser49Gly多态性在原发性高血压 (essentialhypertension ,EH)发病机制中的作用。方法 选择 80例EH患者及 85例正常对照者 ,应用聚合酶链反应 -限制性片段长度多态性( polymerasechainreaction restrictionfragmentlengthpolymorphism ,PCR RFLP)技术分析基因多态性。 结果 EH组和对照组的Ser/Ser、Ser/Gly和Gly/Gly基因型频率分别为 :0 79、0 2 1、0和 0 80、0 19、0 0 1(P >0 5)。Ser和Gly的等位基因频率在高血压组和对照组均分别为 0 89和 0 11,两组间无差异 (P >0 5)。这两组的Ser/Gly多态性分布均符合Hardy Weinberg定律。结论 在所研究的中国人群中 。
Objective To study the role of β 1 adrenoceptor gene Ser49Gly polymorphism in the pathogenesis of essential hypertension(EH). Methods Eighty EH and eighty five normotensive subjects were selected to genotyped at Ser49Gly of the β 1 adrenoceptor gene by the technique of polymerase chain reaction restriction fragment length polymorphism(PCR RFLP). Results The frequencies of β 1 adrenoceptor genotypes Ser/Ser, Ser/Gly and Gly/Gly were 0 79, 0 21 and 0 in EH respectively and 0 80, 0 19 and 0 01 in control group respectively( P >0 5). The allelic frequencies of Ser and Gly were 0 89 and 0 11 respectively in both the control and EH group. There were no difference between these two groups( P >0 5). The Ser/Gly distributions of both groups were accorded with Hardy Weinberg equilibrium. Conclusion No association was found between β 1 adrenoceptor gene Ser49Gly polymorphism and the pathogenesis of EH in Chinese.
出处
《高血压杂志》
CSCD
2003年第5期440-442,共3页
Chinese Journal of Hypertension
