摘要
目的 探讨静脉点滴阿奇霉素和鱼腥草治疗小儿下呼吸道感染的临床疗效及其安全性。方法 采用随机对照分组研究 ,观察组使用阿奇霉素 5～ 10mg/kg ,每日 1次 ,加鱼腥草 1～ 3ml/ (kg·d) ,每日 1次静脉滴注 ,疗程 5～ 7d。对照组选用头孢拉定 5 0～ 10 0mg/ (kg·d)加利巴韦林 10mg/ (kg·d)静脉滴注 ,每日 2次 ,疗程 5～ 7d。结果 观察组痊愈率和有效率分别为 72 .5 %和 89.8% ,而对照组的痊愈率和有效率分别为 4 5 .3%和 73.6 % (P <0 .0 1) ,观察组和对照组的不良反应发生率分别为 13.5 %和 10 .8% (P >0 .0 5 )。结论 阿奇霉素加鱼腥草静脉滴注治疗小儿下呼吸道感染临床疗效确切 。
Objective To evaluate the efficacy and safety o f azithromycin and houttuynine sodium in treatment of lower respiratory tract in fections in children.Methods A total of 326 children were randomized to be tre ated either with azithromycin(5～10 mg/(kg·d)) and houttuyni ne sodium injection (1～3 ml/(kg·d)) for 5～7 days ,or with cefradine and ribavirin as control group.Results The percentage of pati ents cured or clinically improved was 89.8% for research group and 73.6% for con trol group.This difference was statistically significant ( P <0.01).Insignific antly ( P >0.05) related adverse events were found in the research group (13.5 %) vs. control group (10.8%).Conclusion Intravenous azithromycin and houttuynine sodiu m injection is effective and safe drug combinations in the treatment of children with lower respiratory tract infections.
出处
《同济大学学报（医学版）》
CAS
2003年第5期423-425,共3页
Journal of Tongji University(Medical Science)
关键词
阿奇霉素
鱼腥草
下呼吸道感染
儿童
azithromycin
houttuynine sodium injection
l ower respiratory tract infections
children
