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金纳多治疗急性脑梗死的临床有效性和安全性评价

Clinical observation of effect of ginaton in treatment of patients with acute ce rebral infarction
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摘要 目的 :观察金纳多注射液治疗急性脑梗死的临床疗效。方法 :选择发病在 7d以内的急性脑梗死患者 6 8例 ,给予金纳多注射液 2 0ml加入 5 %葡萄糖或生理盐水 2 5 0ml中静脉点滴 ,共用 3周。结果 :轻型 4 0例 ,显效率 6 2 .5 % ,有效率 95 % ,治疗前后神经功能缺损评分P <0 .0 1。中型 2 3例 ,显效率39 .1% ,有效率 73.9% ,治疗前后神经功能缺损评分P <0 .0 5。重型 5例 ,显效 1 5 ,有效 2 5 ,治疗前后神经功能缺损评分P >0 .0 5 ,总有效率 85 .3%。结论 :金纳多注射液是治疗急性脑梗死的有效药物 ,特别适用于轻、中型患者。 AIM: To observe the clini cal effect of ginaton in treatment of patients with acute cerebral infarction. METHODS: 68 cases of acute cerebral infarction within 7 days of onset accepted three weeks ginaton therapy. 20 ml of ginaton injection was added to 5% 250 ml glucose solution or 250ml normal saline solution for intravenous d rip. RESULTS: Among 40 mild cases, the significant effective rat e was 62.5 %, and the score effective rate was 95%. The neural function defec tive between pre-treatment and post-treatment showed a high significant differ ence (P< 0.01 ). Among 23 middle cases, the significant effect ive rate was 39.1 %, effective rate was 73.9 %, and the neural function de fective score between pre-treatment and post-treatment showed significant diff erence (P< 0.05 ). In 5 severe cases, 1 case was significant e ffective, 2 cases were effective, and the neural function defective score betwee n pre-treatment and post-treatment was no significant difference. The total ef fective rat was 85.3%. CONCLUSIONS: Ginaton injection is effective agent for tre ating acute cerebral infarction, especially mild cases.
出处 《中国临床药理学与治疗学》 CAS CSCD 2003年第6期699-700,共2页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 药效学 金纳多 脑梗死 疗效 pharmacodynamics ginaton cerebral infarction curative effect
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