摘要
目的 :探讨氧化修饰低密度脂蛋白 (ox LDL)引发的免疫反应在动脉粥样硬化 (AS)发生发展中的作用 ,揭示ox LDL致AS的免疫学机制。方法 :90例冠心病 (CHD)患者 (分为 3组 :稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组 ) ,采用ELISA法检测其血液中ox LDL、ox LDL Ab及ox LDL IC水平。并入选 4 0例健康人群作为对照组。结果 :CHD各组血液中ox LDL、ox LDL Ab及ox LDL IC水平明显高于对照组 ,以急性心肌梗死组为最高。 3项指标的阳性率以ox LDL IC为最高。ox LDL Ab与血清脂蛋白无关 ,与ox LDL呈负相关 ,与ox LDL IC正相关。结论 :ox LDL的免疫反应参与AS的发生发展 。
Objective:To study the immunopathogenesis of ox LDL on the development of atheriosclerosis.Methods:Ninety patients with CHD(3 groups: SA, UA, AMI) were involved in this study and the levels of ox LDL, anti-ox LDL antibodies(ox LDL Ab) and ox LDL containing immune complexes(ox LDL IC) in circulation were determined by ELISA.Results:The levels of ox LDL?ox LDL Ab and ox LDL IC in blood from patients with CHD were significantly higher than those of controls,and the levels of group AMI were the highest.ox LDL Ab was not correlated with serum TG, HDL and LDL. There were negative correlation between the levels of ox LDL Ab and ox LDL,and positive correlation between the levels of ox LDL Ab and ox LDL IC.Conclusion:Oxidative modification of LDL could elicit humoral immune response,the autoantibodies and immune complexes were associated with the presence or progression of arteriosclerosis,it was an inflammatory disease including a series of highly complex humoral?cellular and molecular responses.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2003年第10期588-590,593,共4页
Journal of Clinical Cardiology
关键词
氧化低密度脂蛋白
免疫反应
自身抗体
动脉粥样硬化
Oxidatively modified low density lipoprotein
Immune response
Autoantibody
Atherosclerosis
