摘要
目的 :观察P38MAPK抑制剂对缺血 /再灌注大鼠肾脏功能损伤的保护作用。方法 :夹闭肾动脉制造大鼠肾脏缺血 /再灌注损伤动物模型 ,静脉注射P38MAPK抑制剂阻断P38MAPK信号转导通路 ,测量其对肾功能及细胞因子含量的影响。结果 :肾脏和血浆中TNF -α和IL - 1β含量随缺血 /再灌注时间的延长而升高 ,肾功能损伤也随缺血 /再灌注时间的延长而加重。应用P38MAPK抑制剂可显著降低TNF -α和IL - 1β含量 ,对缺血 /再灌注所致的肾功能损伤具有明显改善作用。结论 :P38MAPK抑制剂可通过抑制致炎因子的产生而减轻缺血
Objective:To observe the protective effect of P38MAPK inhibitor against kidney dysfunction induced by ischemia/reperfusion injury in rats.Methods: Animal model of kidney ischemia/reperfusion injury was duplicated through renal artery occlusion. P38MAPK signal transduction pathway was blocked by venous injection of P38MAPK inhibitor. Renal function and cytokines were assayed.Results:The contents of TNF-α and IL-1β in kidney and plasma increased significantly with the duration of reperfusion. So did the renal function damage.P38MAPK inhibitor notably improved the renal function with the dropping of TNF-α and IL-1β level in kidney and blood. Conclusion: P38MAPK inhibitor can attenuate renal dysfunction induced by ischemia/reperfusion through depressing the production of pro-inflammatory factors.
出处
《西北国防医学杂志》
CAS
2003年第5期361-363,共3页
Medical Journal of National Defending Forces in Northwest China
