摘要
目的 :研究胃癌根治术后行早期肠内营养患者配合相关耳—体穴针刺对机体免疫功能的影响。方法 :3 2例胃癌根治术患者均予等氮、等热量早期肠内营养 8天 (能全力 ,Nutricia提供 ) ,随机分为 2组 ,研究组 (n=16)同时配合相关耳—体穴针刺。两组患者手术前后均定期监测肝功能各项指标、外周血 T细胞亚群、免疫球蛋白、急性炎性反应指标及胃肠道功能恢复时间、并发症发生情况。结果 :两组均无手术并发症及营养支持代谢并发症发生。手术前后 AST、ACT、TBIL、AKP均无升高 ;与术前 (POD0 )比较 ,术后第 1天 (POD1)两组血浆白蛋白均明显下降 (P<0 .0 1) ,外周血 T细胞亚群CD4、CD4/ CD8及血浆球蛋白 Ig G、Ig M、Ig A均明显下降 (P<0 .0 1及 P<0 .0 5) ,而血浆急性炎性反应指标 (IL-6、PGE2 )均显著升高 (P<0 .0 1) ;至 POD8两组血浆白蛋白、外周血 T细胞亚群 CD4、CD4/CD8及血浆球蛋白 Ig G均有提高 ,与对照组比较 ,研究组升高更明显 (P<0 .0 5) ,而急性炎性反应指标 (IL-6、PGE2 )均有所下降 ,研究组下降更明显 (P<0 .0 5) ,同时 ,研究组肠功能恢复较快 ,对早期肠内喂养耐受性好。结论 :对胃癌根治术后行早期肠内喂养的患者予配合相关耳—体穴针刺 ,可有效地刺激机体免疫功能 ,缓解过度的急性炎性反应 ,促进?
Objective:To investigate the effects of acupunctur e at auriculo-and body-accupoints during early PN postoperatively on the immun e function in gastric cancer patients.Methods:32 cases of gastric cancer patients who received early P N(Nutrison Fibre, Nutricia) for 8 days were divided into two groups at randomiza tion after gastrectomy. The experimental group(n=16) received acupuncture at auriculo-and body-accupoints daily. The nutritional assessment, the phenotype (CD 3, CD 4, CD 8) of T-lymphocyte, the IgG, IgM, IgA in peripheral blood a nd the inflammatory responses(IL-6), PGE 2were measured before operation(POD0) and on postoperative day 1 and 8.Results:On day 8,as compared with the control group,the serum albumin rose obviously in the PN-acupuncture group(P<0.05),CD 4 positive cells and CD 4/CD 8 were increased(P<0.05);the levels of IgG were highe r (P<0.05) , and the inflammatory responses (IL-6 , PGE 2) were signific antly decreased (P<0.05).Conclusion:Acupuncture at auriculo-and body-accupoints during early PN postoperatively can positively modulate the postsurgical immunosuppress ive and inflammatory responses.
出处
《肿瘤研究与临床》
CAS
2003年第5期317-319,共3页
Cancer Research and Clinic
关键词
肠内营养
免疫
炎性反应
胃肿瘤
针刺
Parenteral nutition
Immunity
Inflammatory response
Gastric cancer
Acupuncture
