摘要
目的 :研究苄星青霉素、头孢三嗪和阿奇霉素治疗早期梅毒 (一期和二期 )的疗效 ,为临床提供可选择的梅毒治疗方案。方法 :85例不同期的早期梅毒患者分组采用苄星青霉素 2 4 0万 u/次 ,im,1次 /周 ,连续 3周 ;头孢三嗪 1g/次 ,im,1次 /天 ,连续 14天 ;阿奇霉素 ,第一天 1.0一次口服 ,以后 0 .5 /天一次口服 ,连续 14天。结果 :经不同的疗程 ,三种方案治疗早期梅毒 1年内均能达到理想的效果 :治疗一期梅毒时 ,头孢三嗪组平均有效时间最短 ,差异有显著性 (P <0 .0 5 ) ;三组在治疗一期梅毒的平均痊愈时间对比和二期梅毒的平均有效时间及平均痊愈时间对比上差异均无显著性 (均 P >0 .0 5 )。结论 :标准的卞星青霉素治疗方案仍然有效。青霉素过敏患者可选用阿奇霉素治疗 ,在排除交叉过敏的情况下 。
Objective:To provide more treatment scheme for syphilis,benzathine and cenftraxone and azithromycin were employed to evaluat curative effect Methods:85 patients with syphilis(primary syphilis and secondary syphilis) were divided into three groups according to different type and were treated with three therapies alternatively (benzathine 2 400 000u/im,once a week for three times;cettiaxone 1g im,qd for 14 days;oral azithromycin lg the first day and then 500 mg for the following 13 days) Results:Three therapies were all effective for different type early syphilis(primary syphilis and secondary syphilis)after different course of treatment within 1 year.When three therapies were adopted to treat the same type syphilis,average time for four fold RPR titer decline was the shortest in primary syphilis treated with ceftiaxone(0 83)and existed statistic difference(P<0 05),but the average time for four fold RPR titer declination or healling were not statistic difference in primary syphilis and secondary syphilis between three groups Conclusion:Standard treatment was still effective for early syphilis,Ceftriaxone and azithromycin is available to be elected to treat early syphilis when patient is allergic to penicillin
出处
《广西医学》
CAS
2003年第10期1869-1871,共3页
Guangxi Medical Journal
