摘要
本实验在遗传性听源性癫痫大鼠模型上,采用放射免疫分析法(RIA)同时测定了8个脑区的亮-脑啡肽(L-ENK)、β-内啡肽(β-END)、生长抑素(SS)和P物质(SP)在癫痫(EPI)发作前后的动态变化.结果发现:发作各组各脑区L-ENK、β-END比刺激未发作组明显降低,发作过后L-ENK迅速回升;SS和SP在刺激未发作组及发作各组大多数脑区比未刺激组明显升高.表明L-ENK和β-END是一种内源性致痫物质,SS和SP可能是内源性抗痫物质.
We investigated the relationship between neuropeptides and seizures in genetically epilepsy-prone rats, with a model of audiogenic epilepsy. Using RIA, neuropeptides such as leu-enkephalin(L-ENK),(β-endorphin(β-END) , substance P (SP) and somatostatin (SS) were measured in eight brain regions before and after seizures. We found the contents of L-ENK and β-END in these regions of the seizure group were significantly lower than those of the stimulated non-seizure group and that L-ENK increased rapidly after seizures. The contents of SS and SP in most of the regions of stimulated rats were significantly higher than those of non-stimulated rats. The results indicate that L-ENK and B-END play an endogenous convulsant role, whereas SS and SP have endngenous and anticonvulsant effects.
出处
《青岛医学院学报》
1992年第2期87-92,共6页
Acta Academiae Medicinae Qingdao Universitatis
关键词
癫痫
脑啡肽
亮氨酸
内啡肽类
动物
epilepsy
enkephalin
leucine
endorphins
animals
laboratory
rats
