摘要
目的 探讨心肌肌钙蛋白 (CTnⅠ )在诊断急性心肌梗死 (AMI)和不稳定心绞痛 (UAP)的应用价值。方法 对 31例AMI和 4 0例不稳定心绞痛 (UAP)病人进行血清CTnⅠ、肌酸激酶 (CK)和肌酸激酶同功酶 (CK MB)检测 ,并进行两组间比较分析。结果 31例AMI病人中 2 9例病人血清CTnⅠ明显升高 ,4 0例UAP病人中仅 2例血清CTnⅠ轻度升高。血清CTnⅠ诊断AMI的敏感性为 96 7% ,而CK和CK MB的敏感性分别为 80 %、80 %。血清CTnⅠ诊断AMI的特异性为 94 4 % ,而CK MB的特异性为 77 7%、77 7%。CTnⅠ的敏感性和特异性显著高于CK和CK MB(P <0 0 1)。结论 心肌肌钙蛋白Ⅰ对于AMI的诊断具有很高的敏感性和特异性 ,能早期诊断AMI。此外 ,CTnⅠ在鉴别急性心肌梗死和不稳定心绞痛也具有重要的临床价值 ,心肌肌钙蛋白Ⅰ是一种心肌损伤的特异性标志物。
Objective To investigate the applied value of cardia troponin Ⅰ(CTnⅠ) in the clinical diagnosis of acute myocardial infarction(AMI) and unstable angina pectoris(UAP).Methods The serum CTnⅠ,creatine kinase(CK) and creatine kinase MB(CK MB) levels were simultaneously measured in 31 patients with AMI and 40 patients with UAP.Results The sensitivity of CTnⅠ for diagnosis of AMI was 96.7%,which was significantly higher than that of CK and CK MB(80% and 80%,P<0.01).Moreover,the specificity of CTnⅠ was 94.4%,which was remarkably higher than CT and CK MB(77.7% and 77.7%,P<0.01).Conclusion Cardia troponin Ⅰ,which served as a useful cardiac damage marker,has high sensitivity and specificity for AMI and can aid in the early diagnosis of AMI.Moreover,it has significantly clinical value in the differentiation of AMI and UAP.
出处
《中国基层医药》
CAS
2003年第9期858-859,共2页
Chinese Journal of Primary Medicine and Pharmacy
