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Fractalkine及其受体CX3CR1与冠心病 被引量：1

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摘要 趋化因子fractalkine被炎症内皮细胞表达,与受体CX3CR1结合通过黏附和趋化作用、参与免疫及细胞间信息转导以及CX3CR1基因的多态性等多种途径影响动脉粥样硬化的发生和发展。通过对fractalkine蛋白及其受体CX3CR1 V249/Ⅰ249基因水平的检测以及其作用机制的干预,可能成为冠状动脉粥样硬化性心脏病早期诊断和防治的新途径。
作者 陈章强 金希 胡申江
机构地区 浙江大学医学院附属第一医院心内科 浙江大学医学院临床医学一系 浙江大学医学院附属第一医院心内科
出处 《国外医学（老年医学分册）》 2003年第5期195-198,共4页 Foreign Medical Sciences(Geriatrics)
关键词 趋化因子 FRACTALKINE CX3CR1 冠心病 作用机制
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献18

  • 1cDermott DH, Halcox JP, Schenke WH et al. Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis.Circ Res, 2001; 89 (5): 401～407.
  • 2Bazan JF, Bacon KB, Hardiman G et al. A new class of membrane- bound chemokine with a CX3C motif. Nature,1997; 385 (6617): 640～644.
  • 3Nomiyama H, Imai T, Kusuda J et al. Human chemokines fractalkine ( SCYD1 ), MDC ( SCYA22 ) and TARC(SCYA17) are clustered on chromosome 16q 13. Cytogenet Cell Genet, 1998; 81 (1): 10～11.
  • 4Imai T, Hieshima K, Haskell C et al. Identification and molecular characterization of fractalkine receptor CX3CR1,which mediates both leukocyte migration and adhesion. Cell,1997; 91 (4)- 521～530.
  • 5Combadiere C, Csalzwedet K, Smith ED et al. Idenification of CX3CR1, A chemotatic receptor, for the human CX3C chemokine fractalkine and fusion coreceptc, for HIV- 1. J Biol Chem, 1998; 273 (37): 23799～23804.
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  • 8Mizoue LS, Bazan JF, Johnson EC et al. Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N- terminal fragment of CX3CR1.Biochemistry, 1999; 38 (5): 1402～1414 J Exp Med,1998; 188 (8): 1413～1419.
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同被引文献11

  • 1邓开伯,邓开叔,夏宏器.应重视冠心病炎症机制的研究[J].中国心血管杂志,2005,10(5):321-321. 被引量：3
  • 2Wong B W, Wong D, McManus B M. Characterization of fractalkine ( CX3CL1 ) and CX3CR1 in human coronary arteries with native atheroscleros, diabetes mellitus, and transplant vascular disease [ J ]. Cardiovasc Pathol, 2002, 11(6): 332-338.
  • 3Nishimura M, Umehara H, Nakayama T, et al. Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin +/granzyme B + cytotoxic effector lymphocytes that are defined by CX3CR1 expression[J]. J Immunol, 2002, 168( 12): 6173-6180.
  • 4Kerfoot S M, Lord S E, Bell R B, et al. Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions; a mechanism for selective monocyte recruitment [J]. Eur J Immuol, 2003,33(3) : 729-739.
  • 5Gensini G G. A more meaningful scoring system for determining the severity of coronary heart disease [ J ]. Am J Cardiol, 1983, 51 ( 3 ) : 606.
  • 6Freudlich B, Avdalovic N. Use of gelatin/plasma coated flasks for isolating human peripheral blood monocytes[ J]. J Immumol Methods, 1983, 62(1) : 31-37.
  • 7McDermott D H, Halcox J P, Schenke W H, et al. Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis [ J]. Circ Res, 2001,89(5) : 401-407.
  • 8Umehara H, Bloom E T, Okazaki T, et al. Fractalkine in vascular biology: from basic research to clinical disease[ J ]. Arterioscler Thromb Vasc Biol, 2004, 24(1): 34-40.
  • 9Gugl A, Renner W, Seinost G, et al. Two polymorphisms in the fracalkine receptor CX3CR1 are not associated with peripheral arterial disease[J]. Atherosclerosis, 2003, 166(2): 339-343.
  • 10Barlic J, Zhang Y, Foley J F, et al. Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway [ J ]. Circulation, 2006, 114(8): 807-819.

引证文献1

国外医学（老年医学分册）
2003年 第5期

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