摘要
目的 :探讨姜黄素对肝脏损伤的保护作用。方法 :分别建立四氯化碳、D 半乳糖胺及卡介苗加脂多糖诱导小鼠肝脏损伤模型 ,以测定血清谷丙氨酸转换酶 (ALT)、谷草氨基酸转换酶 (AST)、一氧化氮 (NO)和肝匀浆丙二醛 (MDA)含量为指标观察姜黄素对肝脏损伤的保护作用。结果 :姜黄素与阳性对照药联苯双酯相仿 ,均能明显降低动物模型的血清ALT ,AST ,NO和肝匀浆MDA含量。结论
Objective:To Study the protective effect of curcumin on three models of experimental liver injury in mice.Method:The experimental models of live injury were induced by carbon tetrachloride (CCl 4), D galactosamine ( D Gal N), and Bacillus Calmette Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice. Result:Curcumin (50 mg·kg -1 , 100 mg·kg -1 , 150 mg·kg -1 ), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl 4, D Gal N, BCG+LPS.Conclusion:Curcumin showed protective effect against liver injury induced by CCl 4, D Gal N, BCG plus LPS.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第8期756-758,793,共4页
China Journal of Chinese Materia Medica
