摘要
目的 探讨乙体氯氰菊酯 (β CP)对雄性大鼠的睾丸毒性。 方法 成年Wistar雄性大鼠 ,分别以 0、2 0、40和80mg kg剂量的 β CP连续 8周灌胃染毒 ,按常规方法对染毒大鼠进行精子数、精子活动度和精子畸形检测 ,并对睾丸进行组织病理学检查。结果 80mg kg剂量组大鼠活精率 (60 5 % )及精子活动度 (56 55 % )明显低于对照组 (分别为78 75 %和 72 2 0 % ) ,差异有显著性 (P <0 0 5) ,睾丸支持细胞和各级生精细胞发生病理改变。 2 0和 40mg kg剂量组均未见异常。结论 高剂量的 β
Objective To study the effect of β cypermethrin (β CP) on testicular damage in male rats.Methods Adult male Wistar rats were administrated orally with β CP in different doses (20,40,80 mg/kg respectively) for 8 weeks.We examined sperm counts,sperm motility and malformation sperms with routine procedures and performed pathological examination of testicular tissue.Results The rate of viable sperms (60.50%) and the degree of sperm motility (56.55%) in the high dose group were significantly lower than those in the control group (78.75%,72.20% respectively) (P<0 05),pathological change s of testicular Sertoli cells and each level of spermatogenic cells of male rats were also found.No abnormal findings were observed in middle and low dose groups .Conclusion β CP may induce the testicular damage of male rats at the level of high dose.
出处
《卫生毒理学杂志》
CSCD
北大核心
2003年第3期146-148,共3页
Journal of Health Toxicology
