摘要
反应停因使胎儿致畸而被禁用。上世纪 90年代 ,发现该药对麻风病有明显疗效。在近 10年的研究中 ,发现该药对获得性免疫缺陷综合征 (艾滋病 ,AIDS)相关恶液质有一定疗效 ,并具有抗血管新生作用 ,因而已开始试用于恶性疾病。
出处
《天津药学》
2003年第4期68-71,共4页
Tianjin Pharmacy
参考文献15
-
1Huaghes S, Nainggolan L. Products in 1997 : Successes,setbacks and shocks in drug development. Scrip Magazine, 1998,50-89.
-
2D'Amato R J,Loughnan M S,Flynn E, et al. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA, 1991,91 : 4082.
-
3Folkman J, Shing Y. What is angiogenesis ? J Biol Chem, 1992,267 :10931.
-
4Verheul H M, Panigraphy D,Yuan J, et al. Combination oral antiangiogenic therapy with thalidomide and Sulindac inhibits tumor growth in rabbits. Br J Cancer, 1999,79 ( 1 ) : 114.
-
5Kenyon B M,Browne F. D'Amato R J. Effects of thslidomide and related metabolites in a mouse corneal model of neovascularization.Exp Eye Res,1997, 64(6):971.
-
6Kruse F E,Joussen A M. Rohrschneider K, et al. Thalidomide inhibits corneal angiogenesis induced by vascular endothelial growth factor. Groefes. Arch Clin Exp Ophthalmol, 1998,236 (5) : 461.
-
7Mc Carty M F. Thalidomide may inpede cell migration in primates by down-regulating integrin beta-chains:protential therapentic utlity in solid maliguancies, prolifer-ative retinopathy , inflammatory disorders, neoinitial hyoerpasis, and osteoporosis. Med Hypotheses,1997,49(2) :123.
-
8Argiles J M,Carbo N,Lopez Soriano F J, et al. Was tumor necrosis factor alpha respon-sible for the fetal malformations associated with thalidomide in the early 1960s? Med Hypotheses, 1998,50:313.
-
9Mchugh S M Rifkin I R . Deighton J, et al . The immunosrppressive drug thalidomide induces T helper cell type 2 (Th2)and concomitantly inhibits Thl cycakine production in mitogen and antigenstimulated human pertpheral blood mononuclear cell caltores. Clin Exp Immunol. 1995,99 (2), 160.
-
10Fernandez L P,Schlegea P G,Baker J, et al. Does thalidomide affect IL-2 response and production ? Exp Hemotol, 1995,23 (9) :978.
同被引文献5
-
1Alan F.List.New Approaches to the Treatment of Myelodysplasia[J].Oncologist,Apr,2002,7:39.
-
2V.Eleutherakis-Papaiakovou,A.Bamias,and M.A.Dimopoulos,Thalidomide in cancer medicine,Ann[J].Onc,2004,15:1151-1160.
-
3Roussetlot P, Labaume S, Marolleau JP, et al. Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients[J]. Cancer res, 1999,59:1 041-1 048.
-
4Toshiaki H,Teru H,Masaharu A,et al. Arsenic trioxide inhib- its growth of human multiple myeloma cells in the bone marrow microenviroment[J]. Blood, 2001,30 : 375- 377.
-
5陈玉宝,傅卫军,侯健,丁思奇,王东星,袁振刚,孔宪涛.三氧化二砷对骨髓瘤细胞周期及其调节蛋白表达的影响[J].中华血液学杂志,2003,24(4):193-196. 被引量:34
-
1金慰鄂.肿瘤坏死因子及其应用前景[J].医药导报,1990,9(1):4-6.
-
2唐玉芬,王华庆.甲地孕酮治疗厌食或伴有恶液质的晚期肿瘤病人32例临床结果[J].中国肿瘤临床,1995,22(12):896-896. 被引量:3
-
3口服特比萘芬可引起致命性的血恶液质[J].中国处方药,2006,5(10):71-71.
-
4李媛,董蕾.酪酪肽与消化道肿瘤[J].国际消化病杂志,2007,27(1):52-54. 被引量:3
-
5杨晓玲,危佳.醋酸甲地孕酮在晚期恶性肿瘤中的辅助疗效介绍[J].中国药师,2006,9(2):182-183. 被引量:6
-
6方玲芬,徐洪.苦参碱氯化钠注射液无菌检查法方法学研究[J].贵阳医学院学报,2006,31(3):283-284. 被引量:1
-
7王继营,崔黎,丁云霞,林旭.佳迪在晚期恶性肿瘤辅助治疗中的作用[J].临床肿瘤学杂志,2002,7(3):208-209. 被引量:9
-
8梁月琴,郭军华,张秀国.狗口服甲地孕酮后血浆药物浓度测定[J].医学研究杂志,1997,31(10):29-30. 被引量:1
-
9全海英,郑晓林,高云.CT高压增强对比剂渗漏防范措施的效果观察[J].现代医院,2012,12(7):83-85. 被引量:3
-
10冉华伟,崔慧娟.甲地孕酮提高恶性肿瘤患者生活质量的临床研究[J].中国医院用药评价与分析,2008,8(10):779-781. 被引量:1