摘要
本文研究急性心肌缺血氧自由基及其清除剂对抗凝血酶及纤溶系统的影响。结果表明:心肌缺血4小时引起血浆丙二醛(MDA)增高,血浆抗凝血酶Ⅲ(AT-Ⅲ)及组织型纤溶酶原激活剂(t-PA)活性降低。纤溶酶原激活剂抑制物(PAI)活性增高。MDA与AT-Ⅲ呈负相关,与PAI呈正相关。自由基清除剂超氧化物歧化酶(SOD)及过氯化氢酶(CAT)可降低自由基,升高AT-Ⅲ与t-PA活性,降低PAI活性。作者认为氧自由基可能对急性心肌缺血产生高凝状态起重要作用。
The study was to observe the effect of oxygen free radical and free radical scavengers to antithrombin and fibrinolytie system. The results showed: The blood Plasma value of malondialdehyde (MDA) rose, Antithrombin(AT-Ⅲ) and tissue-type plasminogen activator (t-PA) activity were lower, plasminogen activator inhibitor(PAI) activity was higher after myocardial ischemia 4 hours than before in control group. There was a negative correlation between MDA and AT-Ⅲ, and a positive correlation between MDA and PAI. The free radical scavengers superoxide desmntase (SOD) and catalase (CAT) could decrease MDA and PAl activity, increase AT-Ⅲ and tPA activity. The authors suggested that oxygen free radical may play a majoy role in hypercoagulable state during myocardial ischemia.
关键词
纤溶酶原
游离基
心肌缺血
Oxygen free radical
Antithrombin-III
Tissue-type plasminogen activator
Plasminogen activator inhibitor
Myocardial ischemia
