摘要
为了了解国人人群脂蛋白(a)的分布及水平,探讨脂蛋白(a)与冠心病及其它血脂与载脂蛋白的关系,本文应用单价抗载脂蛋白(a)及抗载脂蛋白B抗体夹心酶联法测定668名健康人血浆脂蛋白(a),测得(?);122.34±141.97mg/L,M为81.07mg/L(0～1 250mg/L),呈典型的正偏态分布,无性别年龄差异,与其它脂类及载脂蛋白不相关。48例冠心病患者血浆脂蛋白(a)水平及>200mg/L的频率分布均明显高于同年龄对照组,提示高脂蛋白(a)水平是致动脉粥样硬化的一个独立危险因素。
Plasma lipoprotein(a) levels were determined by a selective bi-site immunoenzymatic procedure using monospecific antibodies against apo(a) and apo B in 668 healthy people. The mean and median of its concentration were respectively 122.34±141.97mg/L, 81.07mg/L (0～1 250mg/L) and its frequency distribution was markely skewed in positive direction. The differents of sex and age were not significant. This association was independent on the known risk factor for coronary heart disease,such as the concentrations of total cholesterol, triglycerol,HDL-cholesterol, LDL-cholesterol,apoAI and apoB. plasma Lp(a) levels and>200mg/L frequency distribution in 48 patients with coronary heart disease were significantly higher than the control grop. It suggests Lp(a) lipoprotein as an independent risk factor for atherosclerosis.
关键词
ELISA
脂蛋白A
冠心病
Enzyme-linked immunosorbent assay
Lipoprotein(a)
Coronary heart disease
