摘要
①目的 观察托吡酯 (TPM)治疗 4 2例儿童非灶性全身强直阵挛发作 (GTCS)性癫痫的长期效果。②方法 TPM治疗的平均时间为 5 98d(2 35～ 72 0d) ,平均剂量为 4 .8mg·kg-1·d-1。统计TPM经加量期和稳定期后继续治疗 3个月和 6个月与基线相比发作次数减少的比例。③结果 维持治疗 3个月和 6个月GTCS频率减少≥ 5 0 %者分别为 86 %、89% ;发作减少≥ 75 %者分别为 6 4 %和 6 6 % ;而 5 5 %和 5 8%的病儿无发作持续 3～ 6个月以上。最常见的为中枢神经系统的不良事件。经过 2年的治疗 ,4例病儿因不良事件的发生 ,3例病儿发作未得到适当的控制而未继续用药。④结论 TPM长期开放性治疗儿童非灶性全身强直阵挛性癫痫具有良好的耐受性和安全性 ,尤可用于不能明确区分或分类的癫痫综合征。
Objective To study the effects of topiramate (TPM) in 42 children with nonfocal generalized tonic-clonic seizures (GTCS). Methods The mean duration of TPM treatment was 598 days (235～720 days), with the mean TPM dosage of 4.8 mg/kg bodyweight/daily. The reduction in the frequency after three and six months of TPM therapy was compared with the baseline by self-control. Results The seizure frequency of GTCS was reduced by 50% and above from baseline in 86% and 89% of the patients, and by 75% and above from baseline in 64% and 66% of the patients by the end of three and six months, respectively .The ratio of seizure-free patients was 55% and 58% by the end of three and six months, respectively. The most common adverse events were related to the central nervous system. Over the 2-year period of the treatment, only seven(16%) patients discontinued TPM therapy because of adverse effects or uncontrolled seizure. Conclusion TPM therapy is well tolerated and safe for long-term administration by open-label study in GTCS patients, especially for those with unidentified seizure type. TPM can be a general antiepileptic drug (AED) for long-term seizure control when the basic AED therapy is not effective.
出处
《齐鲁医学杂志》
2003年第4期388-389,391,共3页
Medical Journal of Qilu
