摘要
①目的 观察脑血栓形成病人急性期血浆氧化型低密度脂蛋白 (oxLDL)、纤溶酶原激活物抑制物(PAI 1)的变化 ,并探讨二者与脑血栓形成发生的关系。②方法 以 4 0例脑血栓形成病人为CTB组 ,2 3例健康成人作为对照组。分别用双抗夹心ELISA法及发色底物法测定血浆oxLDL、PAI 1水平。③结果 CTB组oxLDL、PAI 1水平明显高于对照组 (t =5 .386、2 .0 4 8,P <0 .0 1、0 .0 5 ) ;CTB组oxLDL与PAI 1水平呈显著正相关 (r =0 .392 ,P <0 .0 1)。④结论 oxLDL、PAI 1可能参与了脑血栓形成的发生 ;PAI 1可能是oxLDL与脑血栓形成的中间环节 。
Objective To observe the levels of oxLDL,PAI-1 and study their roles in patients with cerebrothrombosis. Methods Forty cases of cerebrothrombosis were selected as CTB group and 23 healthy subjects as the control group. The plasma levels of oxLDL and PAI-1 were detected. Results The levels of oxLDL and PAI-1 of CTB group were significantly higher than those of the control group (t=5.386, 2.048, P<0.01, 0.05). The PAI-1 level had a linear positive correlation with oxLDL ( r=0.392,P<0.01). Conclusion Both oxLDL and PAI-1 may participate in the pathogenesis of cerebrothrombosis. PAI-1 may be the link between oxLDL and cerebrothrombosis.
出处
《齐鲁医学杂志》
2003年第3期245-246,共2页
Medical Journal of Qilu
