摘要
①目的 对抗神经衰弱冲剂的长期毒性进行实验研究。②方法 用剂量为生药 110 0mg/kg(低剂量组 )、生药 10 30 0mg/kg(中剂量组 )、生药 342 0 0mg/kg(高剂量组 )抗神经衰弱冲剂给大鼠灌胃 ,对照组用生理盐水灌胃。连续用药 90d后 ,每组取 14只大鼠 ,取血测定血液学及血液生化学指标 ,将大鼠处死后进行系统尸解和病理组织学检查。各组剩余大鼠停止用药 ,继续喂养观察 ,2 8d后取血处死 ,进行可逆行实验。③结果 在用药期间及可逆性恢复期 ,3个用药组及对照组间的血液学指标、血液生化学指标、脏器系数的差别无统计学意义 (F =0 .0 106～ 2 .6 75 1,P >0 .0 5 ) ;3个用药组大鼠的心、肝、脾、肾、肾上腺、胸腺、甲状腺、胃、肠、睾丸、附睾、前列腺、精囊腺、子宫、卵巢、垂体各脏器的组织学观察结果与生理盐水组比较 ,未显示异常或特殊改变。④结论 抗神经衰弱冲剂长期大量口服 ,对大鼠无明显损害 ,未显示因蓄积对大鼠产生的毒性反应 ,是一种安全可靠的药物。
Objective\ To observe the long term toxicity of anti neurasthenia medicine on experimental rats. \ Methods The anti neurasthenia medicine was administered to the rats which were divided into high dose group (34 200 mg/kg),middle dose group (10 300 mg/kg), and low dose group (1 100 mg/kg) for 90 d. Physiological saline was given to the rats in the control group. Hematological,hemato biochemical,visceral,systematic postmortem and pathological examinations were done for 14 rats of each group. The rest of the rats were left for reversible experiment.\ Results\ The effects on hematology and hemato biochemistry and viscera index were not significantly different( F=0.010 6-2.675 1,P >0.05)among the four groups. No abnormal changes were found in the histology of the heart,liver,spleen,kidney,adrenal gland,thymus,thyroid,stomach,intestines,testes,uterus and other organs of the rats in the medicine groups. \ Conclusion\ Long term oral application of the anti neurasthenia medicine has no harm and no toxic effect on rats.
出处
《青岛大学医学院学报》
CAS
2003年第3期331-333,共3页
Acta Academiae Medicinae Qingdao Universitatis
