摘要
目的探讨高同型半胱氨酸 (Hcy)血症与脑梗死、帕金森病 (PD)的关系。方法选择年龄及性别基本匹配的脑梗死组60例、PD组15例和正常老年组30例 ,采用酶联免疫分析法测定被检者血浆Hcy浓度 ,并同时测定叶酸和维生素B12。结果脑梗死组和PD组的血Hcy浓度分别是 (17.15±4.63)μmol/L、(15.65±2.70) μmol/L ,明显高于正常老年组 (10.12±2.62) μmol/L。另外 ,经相关回归分析示 :被检者血中Hcy水平与叶酸、维生素B12 存在负相关。结论脑梗死组、PD组及正常老年组之间血中Hcy水平不尽相同。Hcy水平与脑梗死、PD的发生有一定联系 ,并与叶酸、维生素B12 呈负相关。因此补充营养元素叶酸、维生素B12 可能有助于降低Hcy水平及其危险因素。
Objective To investigate the relationship between hyperhomocysteinemia,cerebral infarction and Parkinson's disease.Methods There were no significant differences in age and sex among three groups ran-domly selected.The plasma homocysteine(Hcy)levels of60patients with cerebral infarction,15patients with Parkinson's disease(PD)and30normal control elderly group were measured by STE.Beside Hcy,every patient should have laboratory examination including folate,Vitamin B 12 .Results The mean plasma Hcy level in cerebral infarction(17.15±4.63)μmol/L or in PD(15.65±2.70)μmol/L was significantly higher than in normal control elderly group(10.12±2.62)μmol/L.Correlation analysis found that plasma Hcy in inspected individuals was negatively correlated with plasma folate and Vitamin B 12 .Conclusions The levels of Hcy were different among cerebral infarction,PD and normal control eldersly group.Hcy might be associated with cerebral infarction and PD.Moreover,the negative relationship existed between Hcy and folate,Vitamin B 12 .Therefore folate and Vita-min B 12 supplementation could lower Hcy level and risk factors.
出处
《中国微循环》
2003年第4期211-213,共3页
Journal of Chinese Microcirculation
