期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Alzheimer病大鼠学习记忆能力与泛素水平 被引量：3

Establishment of dementia rat model by intrahippocampal septal graft with fimbria-fornix lesions and measurement of ubiquitin level
暂未订购
导出
摘要 目的　观察 Alzheimer病 (AD)大鼠行为学及泛素水平。方法　应用脑立体定位仪定位 ,切断大鼠穹隆海马伞制备 AD大鼠模型 ,用Y型迷宫对大鼠进行学习及记忆的观察 ,免疫组化法及蛋白印迹技术检测海马区泛素水平。结果　 AD大鼠 2 w后学习获得和记忆再现的尝试次数增加 ,手术组海马区的泛素表达程度明显高于对照组 (P<0 .0 1 )。结论　 AD大鼠学习及记忆能力受损 ,穹隆海马伞切断大鼠海马区泛素水平明显升高。
作者 任艳 吴哲 胡丽葵
机构地区 中国医科大学附属第一医院神经内科 鞍山钢铁公司铁西医院神经内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2003年第8期536-538,共3页 Chinese Journal of Gerontology
关键词 ALZHEIMER病 大鼠 学习记忆能力 泛素 脑立体定位仪 穹隆海马伞 免疫组化法 蛋白印迹技术
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献7

  • 1张巍,袁云,陈清棠.运动神经元病的病理进展和泛素阳性包涵体[J].中华神经科杂志,2001,34(5):308-310. 被引量：1
  • 2DeSalle LM,Pagano M. Regulation of the G1 to S transition by the ubiquitin pathway [J]. FEBS Lett, 2001,490(3) : 179-189.
  • 3Jeltsch H,Cassel JC,Neufang B,et al. The effects of intrahippocampal raphe and/or septal grafs in rats with fimbria-fornix lesion depend on the origin of the grafted tissue and the behavioral task used [J]. Neurosience,1994;63:19-39.
  • 4Hershko A,Ciechanove A,Vershavsky A,et al. The ubiquitin system [J]. Nat Med,2000;6(10) :1073-1081.
  • 5Wang GP,Khatoon S,Iqbal K,et al. Brain ubiquitin is markedly elevated in Alzheimer's disease [J]. Brain Res 1991,566(1-2) : 146-151.
  • 6Blennow K,Davisson P,Wallin A,et al. Ubiquitin in cerebral spinal fluid in Alzheimer's disease and vascular dementia [J] .Int Psychogeriatr. 1994 ; 6 (1)13-22 : 59-60.
  • 7Pallares-Trujillo J,Lopez-Soriano FJ,Argiles JM. The involvement of the ubiquitin system in Alzheimer'sdisease (review)[J]. Int J Mol Med,1998;2(1) :3-15.

二级参考文献3

  • 1Qiu J H，J Neurosci，2000年，20卷，259页
  • 2Su M，Clin Neuropathol，1999年，18卷，293页
  • 3Arima K，Acta Neuropathol，1998年，96卷，75页

同被引文献40

  • 1[3]Gastman BR, Yin XM, Johnson DE, et al. Tumor-induced apoptosis of T cells: amplification by a mitochondrial cascade[ J ]. Cancer Res, 2000,60(24) :6811 -6817.
  • 2[5]Jeltsch H, Gassel JC, Neufang B, et al. The effects of intrahippocampal raphe and/or septal grafts in rats with fimbria-fomix lesion depend on the origin of the grafted tissue and the behavioral task used [ J ]. Neuroscience, 1994,63 ( 1 ): 19 - 39.
  • 3[7]John QT, Madhumalti MD,Mluise S,et al. Localization of the mitogen activated protein kinase ERK2 in Alzheimer' s disease neurofibrillary tangles and senile plaque neuritis[J]. Brain Res, 1993,618(2) :333 -337.
  • 4[8]Arendt T, Holzer M, Grobmann A, et al. Increased expression and subcellular translocation of the mitogen activated protein kinase and mitogen activated protein kinase in Alzheimer' disease [ J ]. Neuroscience, 1995,68( 1 ) :5 - 18.
  • 5[9]Kim SC, Hahn JS, Min YH, et al. Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinsse,and downregulation of a phosphatase, PACI [J]. Blood,1999,93(11) :3893 -3899.
  • 6Gastman BR, Yin XM, Johnson DE, et al . Tumor-induced apoptosis of T cells: amplification by a mitochondrial cascade[J]. Cancer Res, 2000; 60(24):6811-6817.
  • 7Lin LH, Doherty DH, Lile JD, et al . GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons[J]. Science, 1993;260(5111) :1130-1132.
  • 8Takihino K, Johan F, Willyl B. Loss of inositol 1,4,5-triphosphate receptor sitees and decreased PKC levels correlate with staging of Alzheimer'disease neurofibrillary pathology[J].Brain Res,1998;796(2): 209-221.
  • 9Shimohama S, Matsushima H.Singnal transduction mechanisms in Alzheimer disease[J].Alzheimer Dis Assoc Disord, 1995; 9 (Suppl 2):15-22.
  • 10Chachin M, Shimohana S, Kunugi Yu, et al . Assessement of protein Kinase C mRNA levels in Alzheiimer's disease brains[J].Jpn J Pharmacl, 1996;71(2): 175-177.

引证文献3

二级引证文献6

中国老年学杂志
2003年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部