摘要
综述5-HT1A-受体激动剂抗抑郁作用的机制及其新产品的研究与开发。5-HT1A受体激动剂通过激动突触后膜 的5-HT1A受体,负反馈抑制海马5-HT能神经元上的自主受体而发挥抗抑郁作用,克服了传统抗抑郁药的滞后效应。
5-HT1Aagonists, getting over the lagging effect of traditional antidepressants, act as antidepres-sants by exciting 5-HT1A receptors and inhibiting presynaptic 5-HT1A autoreceptors through negative feedback. In this paper, the acting mechanism and development of this class of antidepressants were highlighted.
出处
《药学进展》
CAS
2003年第4期213-216,共4页
Progress in Pharmaceutical Sciences
